Jekyll and Hyde: evolving perspectives on the function and potential of the adult liver progenitor (oval) cell

Belinda Knight, Vance Matthews, John Olynyk, George Yeoh

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The liver progenitor cell (LPC) has enormous potential for use in cell therapy to treat liver disease. Since liver regenerates readily from pre-existing heatocytes, a role for LPCs and, indeed, their existence have been questioned. Research during the last decade has established that LPCs are an important alternative source of cells for liver regeneration. Their utility for cell therapy lies in their ability to generate both hepatocytes and cholangiocytes. However, they are observed in liver diseases that often lead to cancer and there is experimental evidence that implicates LPCs as the source of tumours. This article provides a brief history of the studies that established the functional importance of LPCs in liver disease. It focuses on mouse models that have led to the identification of factors that regulate LPC growth and differentiation and discusses LPCs derived from different sources. Recent promising results from both in vitro and vivo studies suggest that LPCs could be useful for cell therapy. In the context of liver disease, LPCs may indeed be the cell of the future and understandably "our favourite cell". (c) 2005 Wiley Periodicals, Inc.
Original languageEnglish
Pages (from-to)1192-1202
JournalBioEssays
Volume27
Issue number11
DOIs
Publication statusPublished - 2005

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Liver
Liver Diseases
Stem Cells
Cell- and Tissue-Based Therapy
Liver Regeneration
Cell Differentiation
Hepatocytes
Neoplasms
Cell growth
Growth
Research
Tumors
Identification (control systems)

Cite this

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title = "Jekyll and Hyde: evolving perspectives on the function and potential of the adult liver progenitor (oval) cell",
abstract = "The liver progenitor cell (LPC) has enormous potential for use in cell therapy to treat liver disease. Since liver regenerates readily from pre-existing heatocytes, a role for LPCs and, indeed, their existence have been questioned. Research during the last decade has established that LPCs are an important alternative source of cells for liver regeneration. Their utility for cell therapy lies in their ability to generate both hepatocytes and cholangiocytes. However, they are observed in liver diseases that often lead to cancer and there is experimental evidence that implicates LPCs as the source of tumours. This article provides a brief history of the studies that established the functional importance of LPCs in liver disease. It focuses on mouse models that have led to the identification of factors that regulate LPC growth and differentiation and discusses LPCs derived from different sources. Recent promising results from both in vitro and vivo studies suggest that LPCs could be useful for cell therapy. In the context of liver disease, LPCs may indeed be the cell of the future and understandably {"}our favourite cell{"}. (c) 2005 Wiley Periodicals, Inc.",
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Jekyll and Hyde: evolving perspectives on the function and potential of the adult liver progenitor (oval) cell. / Knight, Belinda; Matthews, Vance; Olynyk, John; Yeoh, George.

In: BioEssays, Vol. 27, No. 11, 2005, p. 1192-1202.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Knight, Belinda

AU - Matthews, Vance

AU - Olynyk, John

AU - Yeoh, George

PY - 2005

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AB - The liver progenitor cell (LPC) has enormous potential for use in cell therapy to treat liver disease. Since liver regenerates readily from pre-existing heatocytes, a role for LPCs and, indeed, their existence have been questioned. Research during the last decade has established that LPCs are an important alternative source of cells for liver regeneration. Their utility for cell therapy lies in their ability to generate both hepatocytes and cholangiocytes. However, they are observed in liver diseases that often lead to cancer and there is experimental evidence that implicates LPCs as the source of tumours. This article provides a brief history of the studies that established the functional importance of LPCs in liver disease. It focuses on mouse models that have led to the identification of factors that regulate LPC growth and differentiation and discusses LPCs derived from different sources. Recent promising results from both in vitro and vivo studies suggest that LPCs could be useful for cell therapy. In the context of liver disease, LPCs may indeed be the cell of the future and understandably "our favourite cell". (c) 2005 Wiley Periodicals, Inc.

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