Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas: Recommendations from the International Society of Gynecological Pathologists

Joseph T. Rabban, C. Blake Gilks, Anais Malpica, Xavier Matias-Guiu, Khush Mittal, George L. Mutter, Esther Oliva, Vinita Parkash, Brigitte M. Ronnett, Paul Staats, Colin J. R. Stewart, W. Glenn McCluggage

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Abstract

This article provides practical recommendations developed from the International Society of Gynecological Pathologists Endometrial Carcinoma Project to address 4 issues that may arise in the diagnosis of uterine corpus low-grade endometrioid carcinoma: (1) The distinction between atypical hyperplasia and low-grade endometrioid carcinoma. (2) The distinction between low-grade endometrioid carcinoma and serous carcinoma. (3) The distinction between corded and hyalinized or spindle cell variants of low-grade endometrioid carcinoma and carcinosarcoma. (4) The diagnostic criteria for mixed endometrial carcinomas, a rare entity that should be diagnosed only after exclusion of a spectrum of tumors including morphologic variants of endometrioid carcinoma, dedifferentiated endometrial carcinoma, carcinosarcoma, and endometrial carcinomas with ambiguous morphology.

Original languageEnglish
Pages (from-to)S25-S39
Number of pages15
JournalInternational Journal of Gynecological Pathology
Volume38
Issue number1
DOIs
Publication statusPublished - Jan 2019

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