© 2015 Elsevier B.V.. The super-large Shuangjianzishan Pb-Zn-Ag deposit is a newly discovered deposit located in the Huanggang-Ganzhuermiao polymetallic metallogenic belt of Inner Mongolia, NE China. The deposit's resource includes 0.026. Mt Ag, 1.1. Mt Pb, and 3.3. Mt Zn. The deposit is controlled by a NW-trending ductile shear zone and NE- and NW-trending faults in black pelite assigned to the lower Permian Dashizhai Formation. LREE enrichment, HREE depletion, Nb, Ta, P, and Ti depletion, and Zr and Hf enrichment characterize felsic magmatic rocks in the Shuangjianzishan Pb-Zn-Ag district. The ages of porphyritic monzogranite, rhyolitic crystal-vitric ignimbrite, and porphyritic granodiorite are 254-252, 169, and 130. Ma, respectively. Pyrite sampled from the mineralization has Re-Os isochron ages of 165. ±. 7. Ma, which suggest the mineralization is associated with the ca. 169. Ma magmatism in the Shuangjianzishan district.Zircons extracted from the porphyritic granodiorite yield εHf(t) values of -11.34 to -1.41, with tDM2 dates of 1275-1901Ma. The εHf(t) values of zircons in the rhyolitic crystal-vitric ignimbrite and the ore-bearing monzogranite porphyry are 7.57-16.23 and 10.18-15.96, respectively, and their tDM2 ages are 177-733 and 257-632Ma, respectively. Partial melting of depleted mantle resulted in the formation of the ca. 254-252Ma ore-bearing porphyritic monzogranite and the ca. 169Ma rhyolitic crystal-vitric ignimbrite; dehydration partial melting of subducted oceanic crust resulted in the formation of the ca. 130Ma porphyritic granodiorite. The porphyritic monzogranite was emplaced during the late stages of closure of the Paleo-Asian Ocean during the transformation from a collisional to extensional tectonic setting. The ca. 170 and ca. 130Ma magmatism and mineralization in the Shuangjianzishan district are related to subduction of the Mongolia-Okhotsk Ocean and subduction of the Paleo-Pacific Ocean Plate, respectively.