Abstract
Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans. © 2013 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 95-102 |
Journal | Prostaglandins and Other Lipid Mediators |
Volume | 107 |
DOIs | |
Publication status | Published - 2013 |