Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

J.M. Galano, Emilie Mas, Anne Barden, Trevor Mori, C. Signorini, C. De Felice, A. Barrett, C.A. Opere, E. Pinot, E. Schwedhelm, R.A. Benndorf, J. Roy, J.Y. Le Guennec, C. Oger, T. Durand

Research output: Contribution to journalReview article

66 Citations (Scopus)

Abstract

Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans. © 2013 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)95-102
JournalProstaglandins and Other Lipid Mediators
Volume107
DOIs
Publication statusPublished - 2013

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