Ischemic preconditioning for cell-based therapy and tissue engineering

S.T. Hsiao, Rodney Dilley, G.J. Dusting, S.Y. Lim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Cell- and tissue-based therapies are innovative strategies to repair and regenerate injured hearts. Despite major advances achieved in optimizing these strategies in terms of cell source and delivery method, the clinical outcome of cell-based therapy remains unsatisfactory. The non-genetic approach of ischemic/hypoxic preconditioning to enhance cell- and tissue-based therapies has received much attention in recent years due to its non-invasive drug-free application. Here we discuss the current development of hypoxic/ischemic preconditioning to enhance stem cell-based cardiac repair and regeneration.

Original languageEnglish
Pages (from-to)141-153
JournalPharmacology & Therapeutics
Volume142
Issue number2
Early online date7 Dec 2013
DOIs
Publication statusPublished - May 2014

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