Is There a Relationship Between Stress in Walls of Abdominal Aortic Aneurysm and Symptoms?

Karol Miller, Hozan Mufty, Alastair Catlin, Christopher Rogers, Bradley Saunders, Ross Sciarrone, Inge Fourneau, Bart Meuris, Angus Tavner, Grand R. Joldes, Adam Wittek

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
65 Downloads (Pure)


Background: Abdominal aortic aneurysm (AAA) is a permanent and irreversible dilation of the lower region of the aorta. It is typically an asymptomatic condition that if left untreated can expand to the point of rupture. In simple mechanical terms, rupture of an artery occurs when the local wall stress exceeds the local wall strength. It is therefore understandable that numerous studies have attempted to estimate the AAA wall stress and investigate the relationship between the AAA wall stress and AAA symptoms. Materials and methods: We conducted computational biomechanics analysis for 19 patients with AAA (a proportion of these patients were classified as symptomatic) to investigate whether the AAA wall stress fields (both the patterns and magnitude) correlate with the clinical definition of symptomatic and asymptomatic AAAs. For computation of AAA wall stress, we used a very efficient method recently presented by the Intelligent Systems for Medicine Laboratory. The Intelligent Systems for Medicine Laboratory's method uses geometry from computed tomography images and mean arterial pressure as the applied load. The method is embedded in the software platform BioPARR—Biomechanics based Prediction of Aneurysm Rupture Risk, freely available from The uniqueness of our stress computation approach is three-fold: i) the results are insensitive to unknown patient-specific mechanical properties of arterial wall tissue; ii) the residual stress is accounted for, according to Y.C. Fung's Uniform Stress Hypothesis; and iii) the analysis is automated and quick, making our approach compatible with clinical workflows. Results: Symptomatic patients could not be identified from the plots (pattern) of AAA wall stress and stress magnitude. Although the largest stress was predicted for a patient who suffered from AAA symptoms, the three patients with the smallest stress were also symptomatic. Conclusions: The results demonstrate, contrary to the common view, that neither the wall stress magnitude nor the stress distribution appears to be associated with the presence of clinical symptoms.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalJournal of Surgical Research
Publication statusPublished - 1 Aug 2020


Dive into the research topics of 'Is There a Relationship Between Stress in Walls of Abdominal Aortic Aneurysm and Symptoms?'. Together they form a unique fingerprint.

Cite this