Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus?

Fathiah S. Amran; Kyle Kim; Andrew Lim; R. Thomson; Silvia Lee; Grant Waterer; Patricia Price

doi:10.1007/s10875-016-0233-1

Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus?

Fathiah S. Amran, Kyle Kim, Andrew Lim, R. Thomson, Silvia Lee, Grant Waterer, Patricia Price

Research output: Contribution to journal › Letter

9 Citations (Scopus)

Abstract

© 2016, Springer Science+Business Media New York. Cytomegalovirus (CMV) establishes lifelong infections with episodes of active replication. We hypothesized that recurrent CMV replication in older individuals may suppress protective immune responses to non-tuberculous mycobacteria (NTM) and so potentiate pulmonary disease. Accordingly, levels of antibodies to three CMV antigen preparations were higher in NTM patients than in age-matched controls. This did not reflect broad-spectrum B cell activation as total immunoglobulin levels were not equivalently increased.

Original language	English
Pages (from-to)	113-116
Number of pages	4
Journal	Journal of Clinical Immunology
Volume	36
Issue number	2
DOIs	https://doi.org/10.1007/s10875-016-0233-1
Publication status	Published - 1 Feb 2016

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10.1007/s10875-016-0233-1

Cite this

@article{fea5a1eeee2c4b408fed87e1993602c8,

title = "Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus?",

abstract = "{\textcopyright} 2016, Springer Science+Business Media New York. Cytomegalovirus (CMV) establishes lifelong infections with episodes of active replication. We hypothesized that recurrent CMV replication in older individuals may suppress protective immune responses to non-tuberculous mycobacteria (NTM) and so potentiate pulmonary disease. Accordingly, levels of antibodies to three CMV antigen preparations were higher in NTM patients than in age-matched controls. This did not reflect broad-spectrum B cell activation as total immunoglobulin levels were not equivalently increased.",

author = "Amran, {Fathiah S.} and Kyle Kim and Andrew Lim and R. Thomson and Silvia Lee and Grant Waterer and Patricia Price",

year = "2016",

month = feb,

day = "1",

doi = "10.1007/s10875-016-0233-1",

language = "English",

volume = "36",

pages = "113--116",

journal = "Journal of Clinical Immunology",

issn = "0271-9142",