Is Curcumin a Safe and Effective Therapeutic in the Treatment against Oral Lichen Planus?

Motahareh Khosrojerdi; Eric Gumpricht; Tannaz Jamialahmadi; Prashant Kesharwani; Amirhossein Sahebkar

doi:10.2174/0929867330666221202150727

Is Curcumin a Safe and Effective Therapeutic in the Treatment against Oral Lichen Planus?

Motahareh Khosrojerdi, Eric Gumpricht, Tannaz Jamialahmadi, Prashant Kesharwani, Amirhossein Sahebkar

UWA Medical School

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Oral lichen planus (OLP) is a chronic mucocutaneous, immunological disease that occurs more frequently in the buccal mucosa of middle-aged female patients. OLP's standard treatment is topical or systemic corticosteroids. Due to corticosteroids’ numerous potential side effects, there is an effort to find an alternative treatment. One alternative treatment is curcumin. Several studies have investigated the effectiveness and safety of curcumin in OLP patients. In this review, we summarized the literature focusing on the effectiveness and safety of curcumin in OLP patients. Our review of clinical trials revealed that either 6000 mg/day curcumin, 80 mg/day nano-curcumin, or 1% curcumin oral gel 6 times/day offered benefits in the treatment of OLP.

Original language	English
Pages (from-to)	1684-1688
Number of pages	5
Journal	Current Medicinal Chemistry
Volume	30
Issue number	15
DOIs	https://doi.org/10.2174/0929867330666221202150727
Publication status	Published - 1 May 2023

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10.2174/0929867330666221202150727

Cite this

@article{59bf10f60a4c4837baaf4aa27da3e21f,

title = "Is Curcumin a Safe and Effective Therapeutic in the Treatment against Oral Lichen Planus?",

abstract = "Oral lichen planus (OLP) is a chronic mucocutaneous, immunological disease that occurs more frequently in the buccal mucosa of middle-aged female patients. OLP's standard treatment is topical or systemic corticosteroids. Due to corticosteroids{\textquoteright} numerous potential side effects, there is an effort to find an alternative treatment. One alternative treatment is curcumin. Several studies have investigated the effectiveness and safety of curcumin in OLP patients. In this review, we summarized the literature focusing on the effectiveness and safety of curcumin in OLP patients. Our review of clinical trials revealed that either 6000 mg/day curcumin, 80 mg/day nano-curcumin, or 1% curcumin oral gel 6 times/day offered benefits in the treatment of OLP.",

keywords = "buccal mucosa, corticosteroids, curcumin, immunological disease, Oral lichen planus, phytomedicine",

author = "Motahareh Khosrojerdi and Eric Gumpricht and Tannaz Jamialahmadi and Prashant Kesharwani and Amirhossein Sahebkar",

note = "Publisher Copyright: {\textcopyright} 2023 Bentham Science Publishers.",

year = "2023",

month = may,

day = "1",

doi = "10.2174/0929867330666221202150727",

language = "English",

volume = "30",

pages = "1684--1688",

journal = "Current Medicinal Chemistry",

issn = "0929-8673",