Iron status and the acute post-exercise hepcidin response in athletes

Peter Peeling, M. Sim, C.E. Badenhorst, Brian Dawson, A.D. Govus, C.R. Abbiss, D.W. Swinkels, Debbie Trinder

Research output: Contribution to journalArticlepeer-review

126 Citations (Scopus)


This study explored the relationship between serum ferritin and hepcidin in athletes. Baseline serum ferritin levels of 54 athletes from the control trial of five investigations conducted in our laboratory were considered; athletes were grouped according to values 100 mg/L (SF>100). Data pooling resulted in each athlete completing one of five running sessions: (1) 8x3 min at 85% vVO2peak; (2) 5x4 min at 90% vVO2peak; (3) 90 min continuous at 75% vVO2peak; (4) 40 min continuous at 75% vVO 2peak; (5) 40 min continuous at 65% vVO2peak. Athletes from each running session were represented amongst all four groups; hence, the mean exercise duration and intensity were not different (p>0.05). Venous blood samples were collected pre-, post- and 3 h post-exercise, and were analysed for serum ferritin, iron, interleukin-6 (IL-6) and hepcidin-25. Baseline and post-exercise serum ferritin levels were different between groups (p0.05). Post-exercise IL-6 was significantly elevated compared to baseline within each group (p100; p
Original languageEnglish
Pages (from-to)6pp
JournalPLoS One
Issue number3
Publication statusPublished - 2014


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