Iron and 8-Isoprostane Levels in Acute and Chronic Wounds

P.S. Yeoh, Michael Stacey

Research output: Contribution to journalArticlepeer-review

101 Citations (Scopus)

Abstract

The purpose of this study was to determine differences in iron and iron protein (ferritin and transferrin) levels in chronic venous ulcers and acute wounds. The deleterious effect of iron in free-radical-induced tissue damage was indirectly examined by assessing 8-isoprostane levels and antioxidant status in wound fluid samples. Wound fluid samples from chronic leg ulcers in nonhealing and healing phases and wound fluid from mastectomy wounds were assayed for ferritin, transferrin, total iron, 8-isoprostane, and total antioxidant status. Immunohistochemistry and Perls' staining were performed on paired biopsies from chronic leg ulcers and on normal skin biopsies. Chronic wound fluid had significantly greater levels of ferritin (p
Original languageEnglish
Pages (from-to)918-925
JournalThe Journal of Investigative Dermatology
Volume121
Issue number4
DOIs
Publication statusPublished - 2003

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