Investigation of the role of epigenetic modification in keloid scar pathology

Mansour Abdullah S Alghamdi

    Research output: ThesisDoctoral Thesis

    1240 Downloads (Pure)

    Abstract

    Keloid scarring is a fibro-proliferative disorder of the skin with no effective treatment and poorly understood pathophysiology. This study investigated epigenetic modification and epithelial-mesenchymal interaction as possible molecular mechanisms important in keloid scarring. Genome-wide DNA methylation and transcriptome analysis was conducted using keloid fibroblasts from 12 patients. An integrated list of differentially methylated and expressed genes was generated. This may represent genes important in keloid pathology. Keratinocyte-fibroblast co-culture experiments showed changes in collagen production in both keloid and normal skin fibroblasts in response to keloid keratinocytes. This suggests epithelial-mesenchymal cross-talk also plays a role in keloid scarring.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Award date25 Oct 2016
    Publication statusUnpublished - 2016

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