TY - CHAP
T1 - Investigation of the Effects of Trehalose on Glycemic Indices in Streptozotocin-Induced Diabetic Rats
AU - Radbakhsh, Shabnam
AU - Momtazi-Borojeni, Amir Abbas
AU - Mahmoudi, Ali
AU - Sarborji, Mohammad Reza
AU - Jamialahmadi, Tannaz
AU - Sathyapalan, Thozhukat
AU - Sahebkar, Amirhossein
PY - 2021
Y1 - 2021
N2 - Background and Aim:: Diabetes is a chronic metabolic disorder with considerable morbidity and mortality because of its associated complications that has become a challenging health problem worldwide. Trehalose (mycose) is a nonreducing disaccharide with a unique therapeutic potency without adverse effects, which has been found to improve glucose metabolism and homeostasis in different diabetes models. We hypothesized that trehalose can reduce blood glucose and improve insulin sensitivity. We have conducted this study to evaluate the effect of trehalose on glycemic indices in streptozotocin (STZ)-induced diabetic rats. Method:: Fourteen diabetic rats were randomly assigned in two treatment groups (seven rats per group) that received trehalose at a dose of 1.5 g/kg/day via oral gavage and a dose of 45 mg/kg/day via intraperitoneal (i.p.) injection. Three control groups, including a positive control, diabetic control (DC), and nondiabetic rats as a normal control group (NC), received metformin (200 mg/kg/day), normal saline, and citrate buffer, respectively. The levels of fasting blood glucose (FBG) were measured at baseline (week 0) and after 4 weeks of treatment. Moreover, an oral glucose tolerance test (OGTT) was performed at the end of the study to determine glucose tolerance. Results:: The results showed that FBG levels were significantly decreased by −66% (−221 ± 65 mg/dL, p = 0.01), −40% (−114 ± 46 mg/dL, p = 0.02), and − 72% (−191 ± 68 mg/dL, p = 0.01) in trehalose-oral, trehalose-i.p., and metformin groups, respectively, after 4 weeks of administration. Evaluating the results of glucose tolerance test and analysis of corresponding areas under the glucose curve (AUCglucose) over 180 min indicated that glucose tolerance was significantly improved in the trehalose-i.p. group (p = 0.03) compared to DC group. Conclusion:: Our findings suggested that trehalose administered via i.p. route might reduce FBG levels and improve glycemic control in STZ-induced diabetic rats.
AB - Background and Aim:: Diabetes is a chronic metabolic disorder with considerable morbidity and mortality because of its associated complications that has become a challenging health problem worldwide. Trehalose (mycose) is a nonreducing disaccharide with a unique therapeutic potency without adverse effects, which has been found to improve glucose metabolism and homeostasis in different diabetes models. We hypothesized that trehalose can reduce blood glucose and improve insulin sensitivity. We have conducted this study to evaluate the effect of trehalose on glycemic indices in streptozotocin (STZ)-induced diabetic rats. Method:: Fourteen diabetic rats were randomly assigned in two treatment groups (seven rats per group) that received trehalose at a dose of 1.5 g/kg/day via oral gavage and a dose of 45 mg/kg/day via intraperitoneal (i.p.) injection. Three control groups, including a positive control, diabetic control (DC), and nondiabetic rats as a normal control group (NC), received metformin (200 mg/kg/day), normal saline, and citrate buffer, respectively. The levels of fasting blood glucose (FBG) were measured at baseline (week 0) and after 4 weeks of treatment. Moreover, an oral glucose tolerance test (OGTT) was performed at the end of the study to determine glucose tolerance. Results:: The results showed that FBG levels were significantly decreased by −66% (−221 ± 65 mg/dL, p = 0.01), −40% (−114 ± 46 mg/dL, p = 0.02), and − 72% (−191 ± 68 mg/dL, p = 0.01) in trehalose-oral, trehalose-i.p., and metformin groups, respectively, after 4 weeks of administration. Evaluating the results of glucose tolerance test and analysis of corresponding areas under the glucose curve (AUCglucose) over 180 min indicated that glucose tolerance was significantly improved in the trehalose-i.p. group (p = 0.03) compared to DC group. Conclusion:: Our findings suggested that trehalose administered via i.p. route might reduce FBG levels and improve glycemic control in STZ-induced diabetic rats.
KW - Diabetes
KW - Insulin tolerance test
KW - Oral glucose tolerance test
KW - Streptozotocin
KW - Trehalose (mycose)
UR - http://www.scopus.com/inward/record.url?scp=85122507870&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-73234-9_33
DO - 10.1007/978-3-030-73234-9_33
M3 - Chapter
C2 - 34981499
AN - SCOPUS:85122507870
SN - 978-3-030-73233-2
T3 - Advances in Experimental Medicine and Biology
SP - 481
EP - 488
BT - Natural Products and Human Diseases
A2 - Sahebkar, Amirhossein
A2 - Sathyapalan, Thozhukat
PB - Springer Heidelberg
CY - Switzerland
ER -
