Investigating the utility of T cell receptor repertoires to inform anti-cancer immunotherapy outcomes

Joel Kidman

doi:10.26182/tpdm-0w49

Investigating the utility of T cell receptor repertoires to inform anti-cancer immunotherapy outcomes

Joel Kidman

School of Biomedical Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

Immune checkpoint blockade (ICB) causes durable tumour responses in a subgroup of patients for some cancers. However, ICB is expensive and causes side effects. Importantly, non-responding patients often do not benefit from ICB, raising the need to develop response biomarkers. T-cells are important for ICB induced anti-tumour immune responses, yet it is unclear if characteristics of T-cells such as T-cell receptor (TCR) repertoire specificity, diversity, phenotype or dynamics can predict response. These chapters aim to advance our overall understanding of T-cells in the context of ICB and may translate to reducing harm to patients that receive no benefit from ICB.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Chee, Jonathan, Supervisor Lesterhuis, Willem, Supervisor Lake, Richard, Supervisor Watson, Mark W., Supervisor, External person
Thesis sponsors	Australian Government Research Training Program
Award date	9 Nov 2023
DOIs	https://doi.org/10.26182/tpdm-0w49
Publication status	Unpublished - 2022

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10.26182/tpdm-0w49

THESIS - DOCTOR OF PHILOSOPHY - KIDMAN Joel Francis - 2022
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1 Review article

Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses
Kidman, J., Principe, N., Watson, M., Lassmann, T., Holt, R. A., Nowak, A. K., Lesterhuis, W. J., Lake, R. A. & Chee, J., 14 Oct 2020, In: Frontiers in Immunology. 11, 587014.
Research output: Contribution to journal › Review article › peer-review

Open Access
63 Citations (Scopus)

Cite this

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abstract = "Immune checkpoint blockade (ICB) causes durable tumour responses in a subgroup of patients for some cancers. However, ICB is expensive and causes side effects. Importantly, non-responding patients often do not benefit from ICB, raising the need to develop response biomarkers. T-cells are important for ICB induced anti-tumour immune responses, yet it is unclear if characteristics of T-cells such as T-cell receptor (TCR) repertoire specificity, diversity, phenotype or dynamics can predict response. These chapters aim to advance our overall understanding of T-cells in the context of ICB and may translate to reducing harm to patients that receive no benefit from ICB.",

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AB - Immune checkpoint blockade (ICB) causes durable tumour responses in a subgroup of patients for some cancers. However, ICB is expensive and causes side effects. Importantly, non-responding patients often do not benefit from ICB, raising the need to develop response biomarkers. T-cells are important for ICB induced anti-tumour immune responses, yet it is unclear if characteristics of T-cells such as T-cell receptor (TCR) repertoire specificity, diversity, phenotype or dynamics can predict response. These chapters aim to advance our overall understanding of T-cells in the context of ICB and may translate to reducing harm to patients that receive no benefit from ICB.

KW - T cell repertoire

KW - Immunotherapy

KW - mesothelioma

KW - murine model

KW - T cell receptor

U2 - 10.26182/tpdm-0w49

DO - 10.26182/tpdm-0w49

M3 - Doctoral Thesis

ER -

Investigating the utility of T cell receptor repertoires to inform anti-cancer immunotherapy outcomes

Abstract

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Research output

Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses

Cite this