Investigating the role of epigenetics in scar maintenance

    Research output: ThesisDoctoral Thesis

    642 Downloads (Pure)


    Scar is defined by an aberrant dermal matrix containing excess and densely packed collagen .This study aimed to characterise DNA methylation and gene expression patterns that underlie the production of collagen by scar fibroblasts. Dermal fibroblasts from normal skin and scar were cultured in vitro and profiled using methylation and expression arrays. Bioinformatic analysis identified a set of genes both differentially methylated and expressed in scar fibroblasts compared to normal skin fibroblasts .Modulation of expression of two identified genes altered collagen metabolism. This work suggests scar fibroblasts have a distinct methylome and transcriptome that may underpin aberrant collagen production.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    • Melton, Phillip, Supervisor
    • Fear, Mark, Supervisor
    • Wallace, Hilary, Supervisor
    • Wood, Fiona, Supervisor
    Award date6 Dec 2016
    Publication statusUnpublished - 2016


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