Investigating the relationship between vitamin D status and cognition in middle and older-aged adults: A dose-response approach

Janis Harse

doi:10.26182/v1cp-z752

Investigating the relationship between vitamin D status and cognition in middle and older-aged adults: A dose-response approach

Janis Harse

School of Population and Global Health

Research output: Thesis › Doctoral Thesis

49 Downloads (Pure)

Abstract

This thesis aimed to characterise the dose-response relationship between vitamin D status, measured as circulating levels of 25-hydroxyvitamin D, and cognition in middle and older-aged adults. A systematic review of the observational literature was undertaken, followed by dose-response meta-analyses. Further studies were based on the Busselton Healthy Ageing Study cohort. Results were generally supportive of a nonlinear relationship that was positive up to midrange 25-hydroxyvitamin D levels, and then plateaued. The relationship was stronger in women than men and in adults aged 65 years or over. Adequate vitamin D status (approximately60-80 nM/L) may support cognitive health during ageing.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Murray, Kevin, Supervisor Zhu, Kun, Supervisor Bucks, Romola, Supervisor Hunter, Michael, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	1 May 2024
DOIs	https://doi.org/10.26182/v1cp-z752
Publication status	Unpublished - 2023

Access to Document

10.26182/v1cp-z752

THESIS - DOCTOR OF PHILOSOPHY - HARSE Janis Dorothy - 2023
This work is protected by Copyright. You may print or download ONE copy of this document for the purpose of your own non-commercial research or study. Any other use requires permission from the copyright owner. The Copyright Act requires you to attribute any copyright works you quote or paraphrase.

1 Article
1 Review article

Vitamin D status and cognitive performance in community-dwelling adults: A dose-response meta-analysis of observational studies
Harse, J. D., Marriott, R. J., Zhu, K., Murray, K. & Bucks, R. S., Jul 2023, In: Frontiers in Neuroendocrinology. 70, 14 p., 101080.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
3 Citations (Scopus)

2 Downloads (Pure)
Investigating potential dose–response relationships between vitamin D status and cognitive performance: A cross-sectional analysis in middle-to older-aged adults in the busselton healthy ageing study
Harse, J. D., Zhu, K., Bucks, R. S., Hunter, M., Lim, E. M., Cooke, B. R., Walsh, J. P. & Murray, K., 1 Jan 2022, In: International Journal of Environmental Research and Public Health. 19, 1, 450.
Research output: Contribution to journal › Article › peer-review

Open Access
6 Citations (Scopus)

Cite this

@phdthesis{dce7e94294cb4fe19867c9467beefcf5,

title = "Investigating the relationship between vitamin D status and cognition in middle and older-aged adults: A dose-response approach",

abstract = "This thesis aimed to characterise the dose-response relationship between vitamin D status, measured as circulating levels of 25-hydroxyvitamin D, and cognition in middle and older-aged adults. A systematic review of the observational literature was undertaken, followed by dose-response meta-analyses. Further studies were based on the Busselton Healthy Ageing Study cohort. Results were generally supportive of a nonlinear relationship that was positive up to midrange 25-hydroxyvitamin D levels, and then plateaued. The relationship was stronger in women than men and in adults aged 65 years or over. Adequate vitamin D status (approximately60-80 nM/L) may support cognitive health during ageing.",

keywords = "vitamin D, 25-hydroxyvitamin D, cognition, cognitive health, ageing, global cognition, domain-specific cognition, dose-response",

author = "Janis Harse",

year = "2023",

doi = "10.26182/v1cp-z752",

language = "English",

school = "The University of Western Australia",

}

TY - BOOK

T1 - Investigating the relationship between vitamin D status and cognition in middle and older-aged adults: A dose-response approach

AU - Harse, Janis

PY - 2023

Y1 - 2023

N2 - This thesis aimed to characterise the dose-response relationship between vitamin D status, measured as circulating levels of 25-hydroxyvitamin D, and cognition in middle and older-aged adults. A systematic review of the observational literature was undertaken, followed by dose-response meta-analyses. Further studies were based on the Busselton Healthy Ageing Study cohort. Results were generally supportive of a nonlinear relationship that was positive up to midrange 25-hydroxyvitamin D levels, and then plateaued. The relationship was stronger in women than men and in adults aged 65 years or over. Adequate vitamin D status (approximately60-80 nM/L) may support cognitive health during ageing.

AB - This thesis aimed to characterise the dose-response relationship between vitamin D status, measured as circulating levels of 25-hydroxyvitamin D, and cognition in middle and older-aged adults. A systematic review of the observational literature was undertaken, followed by dose-response meta-analyses. Further studies were based on the Busselton Healthy Ageing Study cohort. Results were generally supportive of a nonlinear relationship that was positive up to midrange 25-hydroxyvitamin D levels, and then plateaued. The relationship was stronger in women than men and in adults aged 65 years or over. Adequate vitamin D status (approximately60-80 nM/L) may support cognitive health during ageing.

KW - vitamin D

KW - 25-hydroxyvitamin D

KW - cognition

KW - cognitive health

KW - ageing

KW - global cognition

KW - domain-specific cognition

KW - dose-response

U2 - 10.26182/v1cp-z752

DO - 10.26182/v1cp-z752

M3 - Doctoral Thesis

ER -

Investigating the relationship between vitamin D status and cognition in middle and older-aged adults: A dose-response approach

Abstract

Access to Document

Fingerprint

Research output

Vitamin D status and cognitive performance in community-dwelling adults: A dose-response meta-analysis of observational studies

Investigating potential dose–response relationships between vitamin D status and cognitive performance: A cross-sectional analysis in middle-to older-aged adults in the busselton healthy ageing study

Cite this