Investigating the relationship between vitamin D status and cognition in middle and older-aged adults: A dose-response approach

Janis Harse

Research output: ThesisDoctoral Thesis

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Abstract

This thesis aimed to characterise the dose-response relationship between vitamin D status, measured as circulating levels of 25-hydroxyvitamin D, and cognition in middle and older-aged adults. A systematic review of the observational literature was undertaken, followed by dose-response meta-analyses. Further studies were based on the Busselton Healthy Ageing Study cohort. Results were generally supportive of a nonlinear relationship that was positive up to midrange 25-hydroxyvitamin D levels, and then plateaued. The relationship was stronger in women than men and in adults aged 65 years or over. Adequate vitamin D status (approximately60-80 nM/L) may support cognitive health during ageing.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Murray, Kevin, Supervisor
  • Zhu, Kun, Supervisor
  • Bucks, Romola, Supervisor
  • Hunter, Michael, Supervisor
Thesis sponsors
Award date1 May 2024
DOIs
Publication statusUnpublished - 2023

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