Investigating the immune mechanisms of anaphylaxis

    Research output: ThesisDoctoral Thesis

    531 Downloads (Pure)

    Abstract

    Anaphylaxis is a systemic allergic reaction thought to be caused via Initial production of allergen-specific lgE antibodies and subsequent triggering of mast cells. However, as confirmed in this thesis, mast cell activation does not occur in ~30% patients and does not account for the rapid amplification of the Immune response. This thesis Investigates the Involvement of other cell types using a variety of approaches. For the first time, neutrophil activation was demonstrated during acute human anaphylaxis. This novel finding represents a potential mechanism driving the rapid amplification phase of anaphylaxis, opening up new avenues for Improved diagnosis and treatment.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Thesis sponsors
    Award date15 Sep 2017
    DOIs
    Publication statusUnpublished - 2017

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