Investigating the immune mechanisms of anaphylaxis

Abbie Francis

doi:10.4225/23/59cda8c5e0669

Investigating the immune mechanisms of anaphylaxis

Abbie Francis

Research output: Thesis › Doctoral Thesis

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Abstract

Anaphylaxis is a systemic allergic reaction thought to be caused via Initial production of allergen-specific lgE antibodies and subsequent triggering of mast cells. However, as confirmed in this thesis, mast cell activation does not occur in ~30% patients and does not account for the rapid amplification of the Immune response. This thesis Investigates the Involvement of other cell types using a variety of approaches. For the first time, neutrophil activation was demonstrated during acute human anaphylaxis. This novel finding represents a potential mechanism driving the rapid amplification phase of anaphylaxis, opening up new avenues for Improved diagnosis and treatment.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Thesis sponsors	Australian Government Research Training Program
Award date	15 Sep 2017
DOIs	https://doi.org/10.4225/23/59cda8c5e0669
Publication status	Unpublished - 2017

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THESIS - DOCTOR OF PHILOSOPHY - FRANCIS Abbie - 2017
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Cite this

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title = "Investigating the immune mechanisms of anaphylaxis",

abstract = "Anaphylaxis is a systemic allergic reaction thought to be caused via Initial production of allergen-specific lgE antibodies and subsequent triggering of mast cells. However, as confirmed in this thesis, mast cell activation does not occur in ~30% patients and does not account for the rapid amplification of the Immune response. This thesis Investigates the Involvement of other cell types using a variety of approaches. For the first time, neutrophil activation was demonstrated during acute human anaphylaxis. This novel finding represents a potential mechanism driving the rapid amplification phase of anaphylaxis, opening up new avenues for Improved diagnosis and treatment.",

keywords = "Anaphylaxis, Allergy, Immunology, Neutrophil, Granulocyte, Mast Cell Tryptase, Mechanism of anaphylaxis",

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year = "2017",

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language = "English",

school = "The University of Western Australia",

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N2 - Anaphylaxis is a systemic allergic reaction thought to be caused via Initial production of allergen-specific lgE antibodies and subsequent triggering of mast cells. However, as confirmed in this thesis, mast cell activation does not occur in ~30% patients and does not account for the rapid amplification of the Immune response. This thesis Investigates the Involvement of other cell types using a variety of approaches. For the first time, neutrophil activation was demonstrated during acute human anaphylaxis. This novel finding represents a potential mechanism driving the rapid amplification phase of anaphylaxis, opening up new avenues for Improved diagnosis and treatment.

AB - Anaphylaxis is a systemic allergic reaction thought to be caused via Initial production of allergen-specific lgE antibodies and subsequent triggering of mast cells. However, as confirmed in this thesis, mast cell activation does not occur in ~30% patients and does not account for the rapid amplification of the Immune response. This thesis Investigates the Involvement of other cell types using a variety of approaches. For the first time, neutrophil activation was demonstrated during acute human anaphylaxis. This novel finding represents a potential mechanism driving the rapid amplification phase of anaphylaxis, opening up new avenues for Improved diagnosis and treatment.

KW - Anaphylaxis

KW - Allergy

KW - Immunology

KW - Neutrophil

KW - Granulocyte

KW - Mast Cell Tryptase

KW - Mechanism of anaphylaxis

U2 - 10.4225/23/59cda8c5e0669

DO - 10.4225/23/59cda8c5e0669

M3 - Doctoral Thesis

ER -

Investigating the immune mechanisms of anaphylaxis

Abstract

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