Investigating the immune mechanisms of anaphylaxis

Abbie Francis

    Research output: Thesis › Doctoral Thesis

    420 Downloads (Pure)

    Abstract

    Anaphylaxis is a systemic allergic reaction thought to be caused via Initial production of allergen-specific lgE antibodies and subsequent triggering of mast cells. However, as confirmed in this thesis, mast cell activation does not occur in ~30% patients and does not account for the rapid amplification of the Immune response. This thesis Investigates the Involvement of other cell types using a variety of approaches. For the first time, neutrophil activation was demonstrated during acute human anaphylaxis. This novel finding represents a potential mechanism driving the rapid amplification phase of anaphylaxis, opening up new avenues for Improved diagnosis and treatment.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Thesis sponsors
    Award date15 Sep 2017
    DOIs
    Publication statusUnpublished - 2017

    Fingerprint

    Anaphylaxis
    Mast Cells
    Neutrophil Activation
    Allergens
    Hypersensitivity
    Antibodies
    Therapeutics

    Cite this

    Francis, Abbie. / Investigating the immune mechanisms of anaphylaxis. 2017.
    @phdthesis{6663897da7b14f4da34cc07604fb69f0,
    title = "Investigating the immune mechanisms of anaphylaxis",
    abstract = "Anaphylaxis is a systemic allergic reaction thought to be caused via Initial production of allergen-specific lgE antibodies and subsequent triggering of mast cells. However, as confirmed in this thesis, mast cell activation does not occur in ~30{\%} patients and does not account for the rapid amplification of the Immune response. This thesis Investigates the Involvement of other cell types using a variety of approaches. For the first time, neutrophil activation was demonstrated during acute human anaphylaxis. This novel finding represents a potential mechanism driving the rapid amplification phase of anaphylaxis, opening up new avenues for Improved diagnosis and treatment.",
    keywords = "Anaphylaxis, Allergy, Immunology, Neutrophil, Granulocyte, Mast Cell Tryptase, Mechanism of anaphylaxis",
    author = "Abbie Francis",
    year = "2017",
    doi = "10.4225/23/59cda8c5e0669",
    language = "English",
    school = "The University of Western Australia",

    }

    Francis, A 2017, 'Investigating the immune mechanisms of anaphylaxis', Doctor of Philosophy, The University of Western Australia. https://doi.org/10.4225/23/59cda8c5e0669

    Investigating the immune mechanisms of anaphylaxis. / Francis, Abbie.

    2017.

    Research output: Thesis › Doctoral Thesis

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    T1 - Investigating the immune mechanisms of anaphylaxis

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    PY - 2017

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    N2 - Anaphylaxis is a systemic allergic reaction thought to be caused via Initial production of allergen-specific lgE antibodies and subsequent triggering of mast cells. However, as confirmed in this thesis, mast cell activation does not occur in ~30% patients and does not account for the rapid amplification of the Immune response. This thesis Investigates the Involvement of other cell types using a variety of approaches. For the first time, neutrophil activation was demonstrated during acute human anaphylaxis. This novel finding represents a potential mechanism driving the rapid amplification phase of anaphylaxis, opening up new avenues for Improved diagnosis and treatment.

    AB - Anaphylaxis is a systemic allergic reaction thought to be caused via Initial production of allergen-specific lgE antibodies and subsequent triggering of mast cells. However, as confirmed in this thesis, mast cell activation does not occur in ~30% patients and does not account for the rapid amplification of the Immune response. This thesis Investigates the Involvement of other cell types using a variety of approaches. For the first time, neutrophil activation was demonstrated during acute human anaphylaxis. This novel finding represents a potential mechanism driving the rapid amplification phase of anaphylaxis, opening up new avenues for Improved diagnosis and treatment.

    KW - Anaphylaxis

    KW - Allergy

    KW - Immunology

    KW - Neutrophil

    KW - Granulocyte

    KW - Mast Cell Tryptase

    KW - Mechanism of anaphylaxis

    U2 - 10.4225/23/59cda8c5e0669

    DO - 10.4225/23/59cda8c5e0669

    M3 - Doctoral Thesis

    ER -

    Francis A. Investigating the immune mechanisms of anaphylaxis. 2017. https://doi.org/10.4225/23/59cda8c5e0669

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    • THESIS - DOCTOR OF PHILOSOPHY - FRANCIS Abbie - 2017

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