Investigating the contribution of genes, fat distribution, and physical inactibity in obstructive sleep apnoea

    Research output: ThesisDoctoral Thesis

    Abstract

    [Truncated abstract] Background and aims: Obstructive Sleep Apnoea (OSA) is a sleep-related breathing disorder characterised by repetitive narrowing and collapse of the upper airway during sleep. Obesity is a common risk factor and therefore many studies account for the confounding influence of obesity on OSA by adjusting for the metric of body mass index (BMI). Nonetheless, the aetiological relationships between OSA and obesity are complex.

    The core aim of the research described in this thesis was to investigate the inter-relationships between OSA and obesity. Specifically, this was achieved by assessing the relationship in terms of genetic, physiological and environmental factors. Associated with the examination of OSA and obesity was the use of a case-control methodology where the control subjects were picked from a general population sample. A methodological investigation into the prevalence of undiagnosed OSA in a Western Australian community was conducted. Additionally, the capacity of a questionnaire-based method to identify subjects without moderate-severe OSA for use as suitable community controls was assessed. The first study examined whether genetic polymorphisms known to be associated with BMI were independently associated with OSA. The second study used dual-energy absorptiometry (DXA) to examine the role of fat distribution on the severity of OSA. The spectrum of severity in OSA is often attributed to variations in fat distribution; however, previous studies in this field have been compromised by small numbers and inadequate acknowledgement of the role of sex on fat distribution. The third component examined the contribution of environmental influences on obesity and OSA by the measurement of daily physical activity. There is evidence that vigorous exercise may modify the risk of OSA.
    LanguageEnglish
    QualificationDoctor of Philosophy
    StateUnpublished - 2013

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    Obstructive Sleep Apnea
    Fats
    Genes
    Obesity
    Sleep
    Body Mass Index
    Genetic Polymorphisms
    Respiration

    Cite this

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    title = "Investigating the contribution of genes, fat distribution, and physical inactibity in obstructive sleep apnoea",
    abstract = "[Truncated abstract] Background and aims: Obstructive Sleep Apnoea (OSA) is a sleep-related breathing disorder characterised by repetitive narrowing and collapse of the upper airway during sleep. Obesity is a common risk factor and therefore many studies account for the confounding influence of obesity on OSA by adjusting for the metric of body mass index (BMI). Nonetheless, the aetiological relationships between OSA and obesity are complex. The core aim of the research described in this thesis was to investigate the inter-relationships between OSA and obesity. Specifically, this was achieved by assessing the relationship in terms of genetic, physiological and environmental factors. Associated with the examination of OSA and obesity was the use of a case-control methodology where the control subjects were picked from a general population sample. A methodological investigation into the prevalence of undiagnosed OSA in a Western Australian community was conducted. Additionally, the capacity of a questionnaire-based method to identify subjects without moderate-severe OSA for use as suitable community controls was assessed. The first study examined whether genetic polymorphisms known to be associated with BMI were independently associated with OSA. The second study used dual-energy absorptiometry (DXA) to examine the role of fat distribution on the severity of OSA. The spectrum of severity in OSA is often attributed to variations in fat distribution; however, previous studies in this field have been compromised by small numbers and inadequate acknowledgement of the role of sex on fat distribution. The third component examined the contribution of environmental influences on obesity and OSA by the measurement of daily physical activity. There is evidence that vigorous exercise may modify the risk of OSA.",
    keywords = "Sleep disordered nreathing, Obesity, DXA, Gene, Physical activity, Exercise, Sedentary, Prevalence",
    author = "L. Simpson",
    year = "2013",
    language = "English",

    }

    TY - THES

    T1 - Investigating the contribution of genes, fat distribution, and physical inactibity in obstructive sleep apnoea

    AU - Simpson,L.

    PY - 2013

    Y1 - 2013

    N2 - [Truncated abstract] Background and aims: Obstructive Sleep Apnoea (OSA) is a sleep-related breathing disorder characterised by repetitive narrowing and collapse of the upper airway during sleep. Obesity is a common risk factor and therefore many studies account for the confounding influence of obesity on OSA by adjusting for the metric of body mass index (BMI). Nonetheless, the aetiological relationships between OSA and obesity are complex. The core aim of the research described in this thesis was to investigate the inter-relationships between OSA and obesity. Specifically, this was achieved by assessing the relationship in terms of genetic, physiological and environmental factors. Associated with the examination of OSA and obesity was the use of a case-control methodology where the control subjects were picked from a general population sample. A methodological investigation into the prevalence of undiagnosed OSA in a Western Australian community was conducted. Additionally, the capacity of a questionnaire-based method to identify subjects without moderate-severe OSA for use as suitable community controls was assessed. The first study examined whether genetic polymorphisms known to be associated with BMI were independently associated with OSA. The second study used dual-energy absorptiometry (DXA) to examine the role of fat distribution on the severity of OSA. The spectrum of severity in OSA is often attributed to variations in fat distribution; however, previous studies in this field have been compromised by small numbers and inadequate acknowledgement of the role of sex on fat distribution. The third component examined the contribution of environmental influences on obesity and OSA by the measurement of daily physical activity. There is evidence that vigorous exercise may modify the risk of OSA.

    AB - [Truncated abstract] Background and aims: Obstructive Sleep Apnoea (OSA) is a sleep-related breathing disorder characterised by repetitive narrowing and collapse of the upper airway during sleep. Obesity is a common risk factor and therefore many studies account for the confounding influence of obesity on OSA by adjusting for the metric of body mass index (BMI). Nonetheless, the aetiological relationships between OSA and obesity are complex. The core aim of the research described in this thesis was to investigate the inter-relationships between OSA and obesity. Specifically, this was achieved by assessing the relationship in terms of genetic, physiological and environmental factors. Associated with the examination of OSA and obesity was the use of a case-control methodology where the control subjects were picked from a general population sample. A methodological investigation into the prevalence of undiagnosed OSA in a Western Australian community was conducted. Additionally, the capacity of a questionnaire-based method to identify subjects without moderate-severe OSA for use as suitable community controls was assessed. The first study examined whether genetic polymorphisms known to be associated with BMI were independently associated with OSA. The second study used dual-energy absorptiometry (DXA) to examine the role of fat distribution on the severity of OSA. The spectrum of severity in OSA is often attributed to variations in fat distribution; however, previous studies in this field have been compromised by small numbers and inadequate acknowledgement of the role of sex on fat distribution. The third component examined the contribution of environmental influences on obesity and OSA by the measurement of daily physical activity. There is evidence that vigorous exercise may modify the risk of OSA.

    KW - Sleep disordered nreathing

    KW - Obesity

    KW - DXA

    KW - Gene

    KW - Physical activity

    KW - Exercise

    KW - Sedentary

    KW - Prevalence

    M3 - Doctoral Thesis

    ER -