Abstract
Cancer is the second leading cause of deaths worldwide. Using microRNAs as therapeutics and their nanoparticle-mediated delivery is one new and innovative approach to overcome the current need for clinical improvements. MicroRNA-7 (miR-7) is a 'tumour suppressor' which results in reduced cell viability and tumour growth. This research explored PGMA-PEI nanoparticles as delivery agents for mlR-7, and small molecules as modulators of endogenous miR-7 expression. This project resulted in the development of a screening platform which successfully identified several small molecule regulators of miR-7, which were found to upregulate miR-7 in human colon and liver cancer cells.
| Original language | English |
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| Qualification | Doctor of Philosophy |
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| Award date | 4 Jun 2018 |
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| Publication status | Unpublished - 2018 |
Access to Document
- THESIS - DOCTOR OF PHILOSOPHY - HORSHAM Jessica Louise - 2018
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