Investigating microRNA-7 as a potential therapeutic in cancer

Jessica Horsham

Research output: ThesisDoctoral Thesis

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Abstract

Cancer is the second leading cause of deaths worldwide. Using microRNAs as therapeutics and their nanoparticle-mediated delivery is one new and innovative approach to overcome the current need for clinical improvements. MicroRNA-7 (miR-7) is a 'tumour suppressor' which results in reduced cell viability and tumour growth. This research explored PGMA-PEI nanoparticles as delivery agents for mlR-7, and small molecules as modulators of endogenous miR-7 expression. This project resulted in the development of a screening platform which successfully identified several small molecule regulators of miR-7, which were found to upregulate miR-7 in human colon and liver cancer cells.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Leedman, Peter, Supervisor
  • Colley, Shane, Supervisor
  • Pfleger, Kevin, Supervisor
Thesis sponsors
Award date4 Jun 2018
DOIs
Publication statusUnpublished - 2018

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