Investigating immune responses to pneumococcal vaccines and respiratory pathogens in high-risk children in Papua New Guinea

Tasmina Rahman

doi:10.26182/cb8r-2j53

Investigating immune responses to pneumococcal vaccines and respiratory pathogens in high-risk children in Papua New Guinea

Tasmina Rahman

Research output: Thesis › Doctoral Thesis

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Abstract

Pneumococcal and non-typeable Haemophilus influenzae (NTHi) pneumonia is a major problem in Papua New Guinean (PNG)infants. Two pneumococcal conjugate vaccines (10-valent or 13-valent PCV) with and without a polysaccharide vaccine booster(PPV) were trialled in PNG. We demonstrated serotype-specific antibody avidity maturation with both PCVs but not the PPV booster; with serotype-specific avidity differences between PCV10 and PCV13. Serotype-independent vaccines are being developed. Patterns of natural pneumococcal and NTHi protein antibody development in PNG infants were different with evidence of maternal transfer of pneumococcal antibody but not NTHi. This information may guide vaccine development to enhance protection from pneumonia.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Richmond, Peter, Supervisor Kirkham, Lea-Ann, Supervisor Thornton, Ruth, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	15 Dec 2021
DOIs	https://doi.org/10.26182/cb8r-2j53
Publication status	Unpublished - 2021

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10.26182/cb8r-2j53

THESIS - DOCTOR OF PHILOSOPHY - RAHMAN Tasmina - 2021
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Cite this

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title = "Investigating immune responses to pneumococcal vaccines and respiratory pathogens in high-risk children in Papua New Guinea",

abstract = "Pneumococcal and non-typeable Haemophilus influenzae (NTHi) pneumonia is a major problem in Papua New Guinean (PNG)infants. Two pneumococcal conjugate vaccines (10-valent or 13-valent PCV) with and without a polysaccharide vaccine booster(PPV) were trialled in PNG. We demonstrated serotype-specific antibody avidity maturation with both PCVs but not the PPV booster; with serotype-specific avidity differences between PCV10 and PCV13. Serotype-independent vaccines are being developed. Patterns of natural pneumococcal and NTHi protein antibody development in PNG infants were different with evidence of maternal transfer of pneumococcal antibody but not NTHi. This information may guide vaccine development to enhance protection from pneumonia.",

keywords = "Streptococcus pneumoniae, Non-typeable Haemophilus influenzae, Pneumococcal conjugate vaccine, Pneumococcal polysaccharide vaccine, Antibody avidity, Pneumococcal carriage, Natural IgG response",

author = "Tasmina Rahman",

year = "2021",

doi = "10.26182/cb8r-2j53",

language = "English",

school = "The University of Western Australia",

}

TY - BOOK

T1 - Investigating immune responses to pneumococcal vaccines and respiratory pathogens in high-risk children in Papua New Guinea

AU - Rahman, Tasmina

PY - 2021

Y1 - 2021

N2 - Pneumococcal and non-typeable Haemophilus influenzae (NTHi) pneumonia is a major problem in Papua New Guinean (PNG)infants. Two pneumococcal conjugate vaccines (10-valent or 13-valent PCV) with and without a polysaccharide vaccine booster(PPV) were trialled in PNG. We demonstrated serotype-specific antibody avidity maturation with both PCVs but not the PPV booster; with serotype-specific avidity differences between PCV10 and PCV13. Serotype-independent vaccines are being developed. Patterns of natural pneumococcal and NTHi protein antibody development in PNG infants were different with evidence of maternal transfer of pneumococcal antibody but not NTHi. This information may guide vaccine development to enhance protection from pneumonia.

AB - Pneumococcal and non-typeable Haemophilus influenzae (NTHi) pneumonia is a major problem in Papua New Guinean (PNG)infants. Two pneumococcal conjugate vaccines (10-valent or 13-valent PCV) with and without a polysaccharide vaccine booster(PPV) were trialled in PNG. We demonstrated serotype-specific antibody avidity maturation with both PCVs but not the PPV booster; with serotype-specific avidity differences between PCV10 and PCV13. Serotype-independent vaccines are being developed. Patterns of natural pneumococcal and NTHi protein antibody development in PNG infants were different with evidence of maternal transfer of pneumococcal antibody but not NTHi. This information may guide vaccine development to enhance protection from pneumonia.

KW - Streptococcus pneumoniae

KW - Non-typeable Haemophilus influenzae

KW - Pneumococcal conjugate vaccine

KW - Pneumococcal polysaccharide vaccine

KW - Antibody avidity

KW - Pneumococcal carriage

KW - Natural IgG response

U2 - 10.26182/cb8r-2j53

DO - 10.26182/cb8r-2j53

M3 - Doctoral Thesis

ER -

Investigating immune responses to pneumococcal vaccines and respiratory pathogens in high-risk children in Papua New Guinea

Abstract

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