Investigating immune responses to pneumococcal vaccines and respiratory pathogens in high-risk children in Papua New Guinea

Tasmina Rahman

Research output: ThesisDoctoral Thesis

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Abstract

Pneumococcal and non-typeable Haemophilus influenzae (NTHi) pneumonia is a major problem in Papua New Guinean (PNG)infants. Two pneumococcal conjugate vaccines (10-valent or 13-valent PCV) with and without a polysaccharide vaccine booster(PPV) were trialled in PNG. We demonstrated serotype-specific antibody avidity maturation with both PCVs but not the PPV booster; with serotype-specific avidity differences between PCV10 and PCV13. Serotype-independent vaccines are being developed. Patterns of natural pneumococcal and NTHi protein antibody development in PNG infants were different with evidence of maternal transfer of pneumococcal antibody but not NTHi. This information may guide vaccine development to enhance protection from pneumonia.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Richmond, Peter, Supervisor
  • Kirkham, Lea-Ann, Supervisor
  • Thornton, Ruth, Supervisor
Thesis sponsors
Award date15 Dec 2021
DOIs
Publication statusUnpublished - 2021

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