Investigating epigenetic regulation of gene expression at singlenucleus resolution in development and neurodevelopmental disorders

Rebecca Simmons

doi:10.26182/5fef-0124

Investigating epigenetic regulation of gene expression at singlenucleus resolution in development and neurodevelopmental disorders

Rebecca Simmons

School of Molecular Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

The human brain consists of billions of cells, arranged and interconnected in sophisticated structures to allow for complex communication and interaction. There are dozens of different types of cells in the brain that form precursor cells early in development and continue to change through to adulthood. My PhD project focussed on using genomic approaches to characterise transcriptional and epigenome states, dynamics, and differences in the brain, in the context of brain development, neuronal stimulation, and neurological disorders. Overall, this work advanced methods for neuroepigenomic analyses and provided new insights into normal and disrupted brain development and function.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Lister, Ryan, Supervisor Freytag, Saskia, Supervisor Small, Ian, Supervisor Millar, Harvey, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	3 Jun 2021
DOIs	https://doi.org/10.26182/5fef-0124
Publication status	Unpublished - 2021

Embargo information

Embargoed from 15/06/2021 to 30/06/2023. Made publicly available on 30/06/2023.

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10.26182/5fef-0124

THESIS - DOCTOR OF PHILOSOPHY - SIMMONS Rebecca- 2021
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Cite this

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Investigating epigenetic regulation of gene expression at singlenucleus resolution in development and neurodevelopmental disorders

Abstract

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