Investigating changes to the immune system and platelet function after non-severe burn injury

Blair Johnson

Research output: ThesisDoctoral Thesis

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Abstract

Burn trauma has been found to increase the long-term risk of a developing a range of morbidities, including infections, cancer, and cardiovascular disease. Immune dysfunction has been implicated in the aetiology of these diseases, and for cardiovascular disease an association with platelet activation is well-documented. We applied a combination of high-dimensional cytometric techniques to assess the immune profile and platelet function in paediatric and adult burn survivors. In this thesis we describe elevated cytokines and altered cell frequencies in children > 3yrs post injury, correlations between wound outcomes and immune markers, and demonstrate platelet hyperreactivity several weeks after injury.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Stevenson, Andrew, Supervisor
  • Fear, Mark, Supervisor
  • Linden, Matthew, Supervisor
  • Wood, Fiona, Supervisor
Thesis sponsors
Award date28 Jun 2023
DOIs
Publication statusUnpublished - 2023

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