Alzheimer's disease (AD) is a devastating neurodegenerative disease that is predicted to reach pandemic status by mid-century. There is currently no effective treatment or cure, despite heightened research efforts worldwide. Changes in lifestyle, such as exercise, are the focus of current research to identify preventative strategies to delay or prevent the onset of AD. Irisin is a recently identified hormone associated with exercise and speculated to be involved with neuroprotective molecular pathways. This thesis is the first investigation of the potential role of irisin as a biomarker of brain health, utilising data from human studies and in vitro experiments.
|Qualification||Doctor of Philosophy|
|Award date||28 May 2018|
|Publication status||Unpublished - 2018|