Investigating a potential role for irisin as a biomarker in the early detection of Alzheimer's disease

Sabine Maria Bird

Research output: ThesisDoctoral Thesis

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Abstract

Alzheimer's disease (AD) is a devastating neurodegenerative disease that is predicted to reach pandemic status by mid-century. There is currently no effective treatment or cure, despite heightened research efforts worldwide. Changes in lifestyle, such as exercise, are the focus of current research to identify preventative strategies to delay or prevent the onset of AD. Irisin is a recently identified hormone associated with exercise and speculated to be involved with neuroprotective molecular pathways. This thesis is the first investigation of the potential role of irisin as a biomarker of brain health, utilising data from human studies and in vitro experiments.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Martins, Ralph, Supervisor
  • Hulse, Gary, Supervisor
  • Brown, Belinda, Supervisor
  • Rainey-Smith, Stephanie, Supervisor
  • Sohrabi, Hamid, Supervisor
  • Gupta, Veer, Supervisor
Thesis sponsors
Award date28 May 2018
DOIs
Publication statusUnpublished - 2018

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