Inverse association between sympathetic nervous system activity and bone mass in middle aged overweight individuals

Elisabeth Lambert; Sarah Phillips; Ainura Tursunalieva; Nina Eikelis; Carolina Sari; John Dixon; Nora Straznicky; Mariee Grima; Markus Schlaich; Gavin Lambert

doi:10.1016/j.bone.2018.03.025

Inverse association between sympathetic nervous system activity and bone mass in middle aged overweight individuals

Elisabeth Lambert, Sarah Phillips, Ainura Tursunalieva, Nina Eikelis, Carolina Sari, John Dixon, Nora Straznicky, Mariee Grima, Markus Schlaich, Gavin Lambert

UWA Medical School

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Background/Purpose: Sympathetic nervous system activation in obesity is associated with impaired cardiovascular and metabolic function. Animal studies have shown a direct link between sympathetic nervous activation and bone health but little is known about this link in humans. This study examined whether sympathetic activation may impact bone health in overweight adults.

Methods: This cross sectional study included 96 overweight or obese middle-aged adults (51 males, mean body mass index: 32.8 kg/m(2), mean age: 55.3 years). Multivariate linear regression models evaluated associations between whole body and leg bone mineral density (BMD) and bone mineral content (BMC) derived from dual energy X-ray absorptiometry and muscle sympathetic nervous system activity (MSNA) measured by micro-neurography.

Results: Older age, male sex and higher weight were associated with higher leg and body BMC and BMD. After adjustment for age, sex and weight, MSNA was significantly inversely associated with total BMC (p = 0.012) and with leg BMC (p <0.01) but was not associated with either total or leg BMD (p = 0.159 and p = 0.063 respectively). When the analysis was sex specific, the relationships between MSNA and total and leg BMC were only significant in males.

Conclusions: Our study indicates that in middle aged overweight or obese males, sympathetic activation may have a deleterious effect on bone mineral content.

Original language	English
Pages (from-to)	123-128
Number of pages	6
Journal	Bone
Volume	111
DOIs	https://doi.org/10.1016/j.bone.2018.03.025
Publication status	Published - Jun 2018

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10.1016/j.bone.2018.03.025

Resistant Hypertension - Causes Consequences and Novel Therapeutic Approaches
Schlaich, M. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/15 → 31/12/20
Project: Research

Cite this

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title = "Inverse association between sympathetic nervous system activity and bone mass in middle aged overweight individuals",

abstract = "Background/Purpose: Sympathetic nervous system activation in obesity is associated with impaired cardiovascular and metabolic function. Animal studies have shown a direct link between sympathetic nervous activation and bone health but little is known about this link in humans. This study examined whether sympathetic activation may impact bone health in overweight adults.Methods: This cross sectional study included 96 overweight or obese middle-aged adults (51 males, mean body mass index: 32.8 kg/m(2), mean age: 55.3 years). Multivariate linear regression models evaluated associations between whole body and leg bone mineral density (BMD) and bone mineral content (BMC) derived from dual energy X-ray absorptiometry and muscle sympathetic nervous system activity (MSNA) measured by micro-neurography.Results: Older age, male sex and higher weight were associated with higher leg and body BMC and BMD. After adjustment for age, sex and weight, MSNA was significantly inversely associated with total BMC (p = 0.012) and with leg BMC (p <0.01) but was not associated with either total or leg BMD (p = 0.159 and p = 0.063 respectively). When the analysis was sex specific, the relationships between MSNA and total and leg BMC were only significant in males.Conclusions: Our study indicates that in middle aged overweight or obese males, sympathetic activation may have a deleterious effect on bone mineral content.",

keywords = "Sympathetic nervous system, Obesity, Bone density, MINERAL DENSITY, OBESITY, METABOLISM, TURNOVER, WOMEN, RISK",

author = "Elisabeth Lambert and Sarah Phillips and Ainura Tursunalieva and Nina Eikelis and Carolina Sari and John Dixon and Nora Straznicky and Mariee Grima and Markus Schlaich and Gavin Lambert",

year = "2018",

month = jun,

doi = "10.1016/j.bone.2018.03.025",

language = "English",

volume = "111",

pages = "123--128",

journal = "Bone",

issn = "8756-3282",

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T1 - Inverse association between sympathetic nervous system activity and bone mass in middle aged overweight individuals

AU - Lambert, Elisabeth

AU - Phillips, Sarah

AU - Tursunalieva, Ainura

AU - Eikelis, Nina

AU - Sari, Carolina

AU - Dixon, John

AU - Straznicky, Nora

AU - Grima, Mariee

AU - Schlaich, Markus

AU - Lambert, Gavin

PY - 2018/6

Y1 - 2018/6

N2 - Background/Purpose: Sympathetic nervous system activation in obesity is associated with impaired cardiovascular and metabolic function. Animal studies have shown a direct link between sympathetic nervous activation and bone health but little is known about this link in humans. This study examined whether sympathetic activation may impact bone health in overweight adults.Methods: This cross sectional study included 96 overweight or obese middle-aged adults (51 males, mean body mass index: 32.8 kg/m(2), mean age: 55.3 years). Multivariate linear regression models evaluated associations between whole body and leg bone mineral density (BMD) and bone mineral content (BMC) derived from dual energy X-ray absorptiometry and muscle sympathetic nervous system activity (MSNA) measured by micro-neurography.Results: Older age, male sex and higher weight were associated with higher leg and body BMC and BMD. After adjustment for age, sex and weight, MSNA was significantly inversely associated with total BMC (p = 0.012) and with leg BMC (p <0.01) but was not associated with either total or leg BMD (p = 0.159 and p = 0.063 respectively). When the analysis was sex specific, the relationships between MSNA and total and leg BMC were only significant in males.Conclusions: Our study indicates that in middle aged overweight or obese males, sympathetic activation may have a deleterious effect on bone mineral content.

AB - Background/Purpose: Sympathetic nervous system activation in obesity is associated with impaired cardiovascular and metabolic function. Animal studies have shown a direct link between sympathetic nervous activation and bone health but little is known about this link in humans. This study examined whether sympathetic activation may impact bone health in overweight adults.Methods: This cross sectional study included 96 overweight or obese middle-aged adults (51 males, mean body mass index: 32.8 kg/m(2), mean age: 55.3 years). Multivariate linear regression models evaluated associations between whole body and leg bone mineral density (BMD) and bone mineral content (BMC) derived from dual energy X-ray absorptiometry and muscle sympathetic nervous system activity (MSNA) measured by micro-neurography.Results: Older age, male sex and higher weight were associated with higher leg and body BMC and BMD. After adjustment for age, sex and weight, MSNA was significantly inversely associated with total BMC (p = 0.012) and with leg BMC (p <0.01) but was not associated with either total or leg BMD (p = 0.159 and p = 0.063 respectively). When the analysis was sex specific, the relationships between MSNA and total and leg BMC were only significant in males.Conclusions: Our study indicates that in middle aged overweight or obese males, sympathetic activation may have a deleterious effect on bone mineral content.

KW - Sympathetic nervous system

KW - Obesity

KW - Bone density

KW - MINERAL DENSITY

KW - OBESITY

KW - METABOLISM

KW - TURNOVER

KW - WOMEN

KW - RISK

U2 - 10.1016/j.bone.2018.03.025

DO - 10.1016/j.bone.2018.03.025

M3 - Article

SN - 8756-3282

VL - 111

SP - 123

EP - 128

JO - Bone

JF - Bone

ER -

Inverse association between sympathetic nervous system activity and bone mass in middle aged overweight individuals

Abstract

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Resistant Hypertension - Causes Consequences and Novel Therapeutic Approaches

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