Invasive Pneumococcal and Meningococcal Disease

Deirdre Fitzgerald; Grant W. Waterer

doi:10.1016/j.idc.2019.08.007

Invasive Pneumococcal and Meningococcal Disease

Deirdre Fitzgerald, Grant W. Waterer

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

28 Citations (Scopus)

Abstract

This review focuses on current knowledge of the epidemiology, prevention, and treatment of invasive pneumococcal (IPD) and meningococcal disease (IMD). IPD decreased significantly with the introduction of effective conjugate vaccines but is on the rise again. Effective antibiotic therapy of IPD includes the combination of a beta-lactam and a macrolide with additional considerations in meningitis. Steroids are mandatory in pneumococcal meningitis but not indicated in pneumococcal pneumonia except in the setting of refractory shock. There is increasing concern about the cardiovascular complications of IPD. IMD continues to be a significant health problem with major concerns about rising antibiotic resistance.

Original language	English
Pages (from-to)	1125-1141
Number of pages	17
Journal	Infectious Disease Clinics of North America
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/j.idc.2019.08.007
Publication status	Published - 1 Dec 2019

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10.1016/j.idc.2019.08.007

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title = "Invasive Pneumococcal and Meningococcal Disease",

abstract = "This review focuses on current knowledge of the epidemiology, prevention, and treatment of invasive pneumococcal (IPD) and meningococcal disease (IMD). IPD decreased significantly with the introduction of effective conjugate vaccines but is on the rise again. Effective antibiotic therapy of IPD includes the combination of a beta-lactam and a macrolide with additional considerations in meningitis. Steroids are mandatory in pneumococcal meningitis but not indicated in pneumococcal pneumonia except in the setting of refractory shock. There is increasing concern about the cardiovascular complications of IPD. IMD continues to be a significant health problem with major concerns about rising antibiotic resistance.",

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AB - This review focuses on current knowledge of the epidemiology, prevention, and treatment of invasive pneumococcal (IPD) and meningococcal disease (IMD). IPD decreased significantly with the introduction of effective conjugate vaccines but is on the rise again. Effective antibiotic therapy of IPD includes the combination of a beta-lactam and a macrolide with additional considerations in meningitis. Steroids are mandatory in pneumococcal meningitis but not indicated in pneumococcal pneumonia except in the setting of refractory shock. There is increasing concern about the cardiovascular complications of IPD. IMD continues to be a significant health problem with major concerns about rising antibiotic resistance.

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KW - Invasive

KW - Meningococcal

KW - Pneumococcal

KW - Treatment

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JO - Infectious Disease Clinics of North America

JF - Infectious Disease Clinics of North America

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ER -

Invasive Pneumococcal and Meningococcal Disease

Abstract

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