Invasive Pneumococcal and Meningococcal Disease

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

This review focuses on current knowledge of the epidemiology, prevention, and treatment of invasive pneumococcal (IPD) and meningococcal disease (IMD). IPD decreased significantly with the introduction of effective conjugate vaccines but is on the rise again. Effective antibiotic therapy of IPD includes the combination of a beta-lactam and a macrolide with additional considerations in meningitis. Steroids are mandatory in pneumococcal meningitis but not indicated in pneumococcal pneumonia except in the setting of refractory shock. There is increasing concern about the cardiovascular complications of IPD. IMD continues to be a significant health problem with major concerns about rising antibiotic resistance.

Original languageEnglish
Pages (from-to)1125-1141
Number of pages17
JournalInfectious Disease Clinics of North America
Volume33
Issue number4
DOIs
Publication statusPublished - 1 Dec 2019

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Pneumococcal Meningitis
Pneumococcal Pneumonia
Conjugate Vaccines
Macrolides
beta-Lactams
Microbial Drug Resistance
Meningitis
Shock
Epidemiology
Steroids
Anti-Bacterial Agents
Health
Therapeutics

Cite this

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title = "Invasive Pneumococcal and Meningococcal Disease",
abstract = "This review focuses on current knowledge of the epidemiology, prevention, and treatment of invasive pneumococcal (IPD) and meningococcal disease (IMD). IPD decreased significantly with the introduction of effective conjugate vaccines but is on the rise again. Effective antibiotic therapy of IPD includes the combination of a beta-lactam and a macrolide with additional considerations in meningitis. Steroids are mandatory in pneumococcal meningitis but not indicated in pneumococcal pneumonia except in the setting of refractory shock. There is increasing concern about the cardiovascular complications of IPD. IMD continues to be a significant health problem with major concerns about rising antibiotic resistance.",
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Invasive Pneumococcal and Meningococcal Disease. / Fitzgerald, Deirdre; Waterer, Grant W.

In: Infectious Disease Clinics of North America, Vol. 33, No. 4, 01.12.2019, p. 1125-1141.

Research output: Contribution to journalReview article

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AB - This review focuses on current knowledge of the epidemiology, prevention, and treatment of invasive pneumococcal (IPD) and meningococcal disease (IMD). IPD decreased significantly with the introduction of effective conjugate vaccines but is on the rise again. Effective antibiotic therapy of IPD includes the combination of a beta-lactam and a macrolide with additional considerations in meningitis. Steroids are mandatory in pneumococcal meningitis but not indicated in pneumococcal pneumonia except in the setting of refractory shock. There is increasing concern about the cardiovascular complications of IPD. IMD continues to be a significant health problem with major concerns about rising antibiotic resistance.

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