Intravenous iron for the treatment of anaemia in critical illness

Research output: ThesisDoctoral Thesis

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Abstract

Anaemia is prevalent in patients admitted to the intensive care unit (ICU) and is the most common indication for red blood
cell (ABC) transfusion. Critically ill patients account for a substantial proportion of the total quantity of this scarce and costly resource. ABC transfusion is also associated with adverse outcomes. The thesis aim was to test the hypothesis that intravenous iron therapy is safe and effective in reducing ABC transfusion requirement in critically ill patients with anaemia who are admitted to the ICU. The thesis includes a systematic review, an observational study, a multicentre randomised controlled trial and nested sub-study.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Webb, Steve, Supervisor
  • Ho, Kwok-ming, Supervisor
  • Erber, Wendy, Supervisor
  • Allan, Jane, Supervisor
Award date23 Jan 2018
DOIs
Publication statusUnpublished - 2018

Fingerprint

Critical Illness
Anemia
Iron
Intensive Care Units
Observational Studies
Therapeutics
Randomized Controlled Trials

Cite this

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title = "Intravenous iron for the treatment of anaemia in critical illness",
abstract = "Anaemia is prevalent in patients admitted to the intensive care unit (ICU) and is the most common indication for red bloodcell (ABC) transfusion. Critically ill patients account for a substantial proportion of the total quantity of this scarce and costly resource. ABC transfusion is also associated with adverse outcomes. The thesis aim was to test the hypothesis that intravenous iron therapy is safe and effective in reducing ABC transfusion requirement in critically ill patients with anaemia who are admitted to the ICU. The thesis includes a systematic review, an observational study, a multicentre randomised controlled trial and nested sub-study.",
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author = "Edward Litton",
year = "2018",
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school = "The University of Western Australia",

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AB - Anaemia is prevalent in patients admitted to the intensive care unit (ICU) and is the most common indication for red bloodcell (ABC) transfusion. Critically ill patients account for a substantial proportion of the total quantity of this scarce and costly resource. ABC transfusion is also associated with adverse outcomes. The thesis aim was to test the hypothesis that intravenous iron therapy is safe and effective in reducing ABC transfusion requirement in critically ill patients with anaemia who are admitted to the ICU. The thesis includes a systematic review, an observational study, a multicentre randomised controlled trial and nested sub-study.

KW - Iron

KW - Anaemia

KW - Critical Illness

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M3 - Doctoral Thesis

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