Intravenous injection of mesenchymal progenitor cells as a therapy for cervical spinal cord injury

Seok Voon Lee

Intravenous injection of mesenchymal progenitor cells as a therapy for cervical spinal cord injury

Seok Voon Lee

Research output: Thesis › Doctoral Thesis

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Abstract

In this thesis, I first examined whether intravenous injection of mesenchymal progenitor cells (MPCs) into mouse cervical contusion and hemisection spinal cord injury (SCI) models can help repair the Injured spinal cord. Next, the potential efficacy of a combinatorial treatment with intravenous Injection of MPCs and intraspinal Injection of neural stem cells into a cervical contusion SCI model was examined. The aim of the third study was to examine if dead cells are an appropriate cell control for cellular transplantation studies. Overall, the results showed that intravenous injection of MPCs at Day 1 post-injury is beneficial for contusive cervical SCI.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Plant, Giles, Supervisor Harvey, Alan, Supervisor
Award date	8 Aug 2016
Publication status	Unpublished - 2016

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THESIS - DOCTOR OF PHILOSOPHY - LEE Seok Voon - 2016 - Part 1
THESIS - DOCTOR OF PHILOSOPHY - LEE Seok Voon - 2016 - Part 2
THESIS - DOCTOR OF PHILOSOPHY - LEE Seok Voon - 2016 - Part 3
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title = "Intravenous injection of mesenchymal progenitor cells as a therapy for cervical spinal cord injury",

abstract = "In this thesis, I first examined whether intravenous injection of mesenchymal progenitor cells (MPCs) into mouse cervical contusion and hemisection spinal cord injury (SCI) models can help repair the Injured spinal cord. Next, the potential efficacy of a combinatorial treatment with intravenous Injection of MPCs and intraspinal Injection of neural stem cells into a cervical contusion SCI model was examined. The aim of the third study was to examine if dead cells are an appropriate cell control for cellular transplantation studies. Overall, the results showed that intravenous injection of MPCs at Day 1 post-injury is beneficial for contusive cervical SCI.",

keywords = "Spinal cord injury, Mesenchymal , Neural stem cells, Intravenous, Cervical, Progenitor cells, Transplantation",

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year = "2016",

language = "English",

school = "The University of Western Australia",

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AU - Lee, Seok Voon

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N2 - In this thesis, I first examined whether intravenous injection of mesenchymal progenitor cells (MPCs) into mouse cervical contusion and hemisection spinal cord injury (SCI) models can help repair the Injured spinal cord. Next, the potential efficacy of a combinatorial treatment with intravenous Injection of MPCs and intraspinal Injection of neural stem cells into a cervical contusion SCI model was examined. The aim of the third study was to examine if dead cells are an appropriate cell control for cellular transplantation studies. Overall, the results showed that intravenous injection of MPCs at Day 1 post-injury is beneficial for contusive cervical SCI.

AB - In this thesis, I first examined whether intravenous injection of mesenchymal progenitor cells (MPCs) into mouse cervical contusion and hemisection spinal cord injury (SCI) models can help repair the Injured spinal cord. Next, the potential efficacy of a combinatorial treatment with intravenous Injection of MPCs and intraspinal Injection of neural stem cells into a cervical contusion SCI model was examined. The aim of the third study was to examine if dead cells are an appropriate cell control for cellular transplantation studies. Overall, the results showed that intravenous injection of MPCs at Day 1 post-injury is beneficial for contusive cervical SCI.

KW - Spinal cord injury

KW - Mesenchymal

KW - Neural stem cells

KW - Intravenous

KW - Cervical

KW - Progenitor cells

KW - Transplantation

M3 - Doctoral Thesis

ER -

Intravenous injection of mesenchymal progenitor cells as a therapy for cervical spinal cord injury

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