Intrauterine Candida albicans infection elicits severe inflammation in fetal sheep

Matt Payne, Matthew Kemp, Suhas Kallapur, P.S. Kannan, Masatoshi Saito, Yuichiro Miura, John Newnham, Sarah Stock, Demelza Ireland, Boris Kramer, Alan Jobe

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Background:Preventing preterm birth and subsequent adverse neonatal sequelae is among the greatest clinical challenges of our time. Recent studies suggest a role for Candida spp. in preterm birth and fetal injury, as a result of their colonization of either the vagina and/or the amniotic cavity. We hypothesized that intraamniotic Candida albicans would cause a vigorous, acute fetal inflammatory response.Methods:Sheep carrying singleton pregnancies received single intraamniotic injections of either saline (control) or 10 7 colony-forming units C. albicans 1 or 2 d prior to surgical delivery and euthanasia at 124 ± 2 d gestation.Results:Colonization of the amniotic cavity by C. albicans resulted in a modest inflammatory response at 1 d and florid inflammation at 2 d, characterized by fetal thrombocytopenia, lymphopenia, and significant increases of inflammatory cytokines/chemokines in the fetal membranes skin, lung, and the amniotic fluid.Conclusion:Acute colonization of the amniotic cavity by C. albicans causes severe intrauterine inflammation and fetal injury. C. albicans is a potent fetal pathogen that can contribute to adverse pregnancy outcomes. Copyright © 2014 International Pediatric Research Foundation, Inc.
Original languageEnglish
Pages (from-to)716-722
JournalPediatric Research
Issue number6
Publication statusPublished - 2014


Dive into the research topics of 'Intrauterine Candida albicans infection elicits severe inflammation in fetal sheep'. Together they form a unique fingerprint.

Cite this