Intra-amniotic corticosteroids for preterm lung maturation in sheep

T.J.M. Moss, N.P. Mulrooney, Ilias Nitsos, M. Ikegami, A.H. Jobe, John Newnham

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    ObjectiveThe purpose of this study was to compare efficacy on fetal lung maturation of intra-amniotic betamethasone or budesonide with the efficacy of maternal intramuscular betamethasone.Study designPregnant ewes received intra-amniotic betamethasone (0.5 mg/kg or 2 mg/kg fetal weight), intra-amniotic budesonide (0.5 mg/kg or 2 mg/kg), maternal intramuscular betamethasone (0.5 mg/kg maternal weight), intra-amniotic saline solution, or maternal saline solution. Lambs were delivered 2 or 7 days later, at 124 days of gestation for measurement of respiratory system compliance, ventilatory efficiency index, and surfactant levels.ResultsLung function increased 2 days after maternal betamethasone, intra-amniotic betamethasone (2 mg/kg), and intra-amniotic budesonide (2 mg/kg) administration and 7 days after maternal betamethasone or intra-amniotic budesonide (2.0 mg/kg) administration. Lung function was not improved 7 days after intra-amniotic betamethasone (2.0 mg/kg) administration or 2 days after intra-amniotic betamethasone (0.5 mg/kg) or intra-amniotic budesonide (0.5 mg/kg) administration. Intra-amniotic corticosteroid administration increased fetal death and respiratory morbidity.ConclusionIntra-amniotic corticosteroid administration improved preterm lung function, but the associated morbidity and mortality rates suggest that they are not suitable for clinical use.
    Original languageEnglish
    Pages (from-to)1389-1395
    JournalAmerican Journal of Obstetrics and Gynecology
    Volume189
    Issue number5
    DOIs
    Publication statusPublished - 2003

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