Overacitivity of the sympathetic nervous system has been identified as one of the main contributors to the complex pathophysiology of resistant hypertension and the development of comorbidities. There is evidence that catheter-based renal sympathetic denervation can lower central sympathetic outflow, reduce whole-body norepinephrine spillover and is associated with substantial and sustained reduction in blood pressure. The results of the randomised controlled "Symplicity HTN-2" trial are required to definitively determine the role of this new method. Interventional sympathetic renal denervation is safe and effective and might be helpful in the management of patients with therapy-resistant hypertension and concomitant comorbidities.
|Number of pages||3|
|Journal||Journal fur Hypertonie|
|Publication status||Published - 8 Oct 2010|