Interventional renal denervation for resistant hypertension

Felix Mahfoud, M. Kindermann, C. Ukena, P. A. Sobotka, I. Kindermann, M. Schlaich, M. Böhm

Research output: Contribution to journalShort survey

Abstract

Overacitivity of the sympathetic nervous system has been identified as one of the main contributors to the complex pathophysiology of resistant hypertension and the development of comorbidities. There is evidence that catheter-based renal sympathetic denervation can lower central sympathetic outflow, reduce whole-body norepinephrine spillover and is associated with substantial and sustained reduction in blood pressure. The results of the randomised controlled "Symplicity HTN-2" trial are required to definitively determine the role of this new method. Interventional sympathetic renal denervation is safe and effective and might be helpful in the management of patients with therapy-resistant hypertension and concomitant comorbidities.

Translated title of the contributionInterventional renal denervation for resistant hypertension
Original languageGerman
Pages (from-to)18-20
Number of pages3
JournalJournal fur Hypertonie
Volume14
Issue number3
Publication statusPublished - 8 Oct 2010
Externally publishedYes

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Sympathectomy
Denervation
Comorbidity
Hypertension
Kidney
Sympathetic Nervous System
Norepinephrine
Catheters
Blood Pressure
Therapeutics

Cite this

Mahfoud, F., Kindermann, M., Ukena, C., Sobotka, P. A., Kindermann, I., Schlaich, M., & Böhm, M. (2010). Interventionelle renale sympathektomie zur behandlung der therapieresistenten hypertonie. Journal fur Hypertonie, 14(3), 18-20.
Mahfoud, Felix ; Kindermann, M. ; Ukena, C. ; Sobotka, P. A. ; Kindermann, I. ; Schlaich, M. ; Böhm, M. / Interventionelle renale sympathektomie zur behandlung der therapieresistenten hypertonie. In: Journal fur Hypertonie. 2010 ; Vol. 14, No. 3. pp. 18-20.
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Mahfoud, F, Kindermann, M, Ukena, C, Sobotka, PA, Kindermann, I, Schlaich, M & Böhm, M 2010, 'Interventionelle renale sympathektomie zur behandlung der therapieresistenten hypertonie' Journal fur Hypertonie, vol. 14, no. 3, pp. 18-20.

Interventionelle renale sympathektomie zur behandlung der therapieresistenten hypertonie. / Mahfoud, Felix; Kindermann, M.; Ukena, C.; Sobotka, P. A.; Kindermann, I.; Schlaich, M.; Böhm, M.

In: Journal fur Hypertonie, Vol. 14, No. 3, 08.10.2010, p. 18-20.

Research output: Contribution to journalShort survey

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T1 - Interventionelle renale sympathektomie zur behandlung der therapieresistenten hypertonie

AU - Mahfoud, Felix

AU - Kindermann, M.

AU - Ukena, C.

AU - Sobotka, P. A.

AU - Kindermann, I.

AU - Schlaich, M.

AU - Böhm, M.

PY - 2010/10/8

Y1 - 2010/10/8

N2 - Overacitivity of the sympathetic nervous system has been identified as one of the main contributors to the complex pathophysiology of resistant hypertension and the development of comorbidities. There is evidence that catheter-based renal sympathetic denervation can lower central sympathetic outflow, reduce whole-body norepinephrine spillover and is associated with substantial and sustained reduction in blood pressure. The results of the randomised controlled "Symplicity HTN-2" trial are required to definitively determine the role of this new method. Interventional sympathetic renal denervation is safe and effective and might be helpful in the management of patients with therapy-resistant hypertension and concomitant comorbidities.

AB - Overacitivity of the sympathetic nervous system has been identified as one of the main contributors to the complex pathophysiology of resistant hypertension and the development of comorbidities. There is evidence that catheter-based renal sympathetic denervation can lower central sympathetic outflow, reduce whole-body norepinephrine spillover and is associated with substantial and sustained reduction in blood pressure. The results of the randomised controlled "Symplicity HTN-2" trial are required to definitively determine the role of this new method. Interventional sympathetic renal denervation is safe and effective and might be helpful in the management of patients with therapy-resistant hypertension and concomitant comorbidities.

KW - Interventional approach

KW - Renal nerve ablation

KW - Sympathetic nervous system

KW - Treatment-resistant hypertension

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JO - Journal fur Hypertonie

JF - Journal fur Hypertonie

SN - 1028-2327

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Mahfoud F, Kindermann M, Ukena C, Sobotka PA, Kindermann I, Schlaich M et al. Interventionelle renale sympathektomie zur behandlung der therapieresistenten hypertonie. Journal fur Hypertonie. 2010 Oct 8;14(3):18-20.