Interrogating the functional diversity of type I interferons to generate tailored therapies for cancer

Hannah Newnes

doi:10.26182/sg5x-7w14

Interrogating the functional diversity of type I interferons to generate tailored therapies for cancer

Hannah Newnes

Research output: Thesis › Doctoral Thesis

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Abstract

Immunotherapies have changed the landscape of cancer treatment. The tumour microenvironment (TME) often dictates response to immunotherapy, whereby a ‘hot’ tumour is more responsive than their ‘cold’ counterparts. However, many patients remain unresponsive to treatment despite having a ‘hot’ tumour. In this thesis, we explored the functional diversity of type I interferons (IFN-I) against cancer. Utilising sequencing technologies, we showed that expression of IFN-I subtypes within the TME identified a third ‘overheated’ category of tumours. Through interrogation of our preclinical models of tumour control versus progression using advanced data analytic pipelines, we identified therapeutic targets that can enhance tumour elimination.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Fernandez, Sonia, Supervisor Foley, Bree, Supervisor Waithman, Jason, Supervisor Armitage, Jesse, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	24 Oct 2023
DOIs	https://doi.org/10.26182/sg5x-7w14
Publication status	Unpublished - 2023

Embargo information

Embargoed from 21/10/2023 to 10/10/2025. Made publicly available on 10/10/2025

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.26182/sg5x-7w14

THESIS - DOCTOR OF PHILOSOPHY - NEWNES Hannah Victoria - 2023

1 Review article

Directing the future breakthroughs in immunotherapy: The importance of a holistic approach to the tumour microenvironment
Newnes, H. V., Armitage, J. D., Audsley, K. M., Bosco, A. & Waithman, J., 1 Dec 2021, In: Cancers. 13, 23, 5911.
Research output: Contribution to journal › Review article › peer-review

Open Access
3 Citations (Scopus)

Cite this

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title = "Interrogating the functional diversity of type I interferons to generate tailored therapies for cancer",

abstract = "Immunotherapies have changed the landscape of cancer treatment. The tumour microenvironment (TME) often dictates response to immunotherapy, whereby a {\textquoteleft}hot{\textquoteright} tumour is more responsive than their {\textquoteleft}cold{\textquoteright} counterparts. However, many patients remain unresponsive to treatment despite having a {\textquoteleft}hot{\textquoteright} tumour. In this thesis, we explored the functional diversity of type I interferons (IFN-I) against cancer. Utilising sequencing technologies, we showed that expression of IFN-I subtypes within the TME identified a third {\textquoteleft}overheated{\textquoteright} category of tumours. Through interrogation of our preclinical models of tumour control versus progression using advanced data analytic pipelines, we identified therapeutic targets that can enhance tumour elimination.",

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AB - Immunotherapies have changed the landscape of cancer treatment. The tumour microenvironment (TME) often dictates response to immunotherapy, whereby a ‘hot’ tumour is more responsive than their ‘cold’ counterparts. However, many patients remain unresponsive to treatment despite having a ‘hot’ tumour. In this thesis, we explored the functional diversity of type I interferons (IFN-I) against cancer. Utilising sequencing technologies, we showed that expression of IFN-I subtypes within the TME identified a third ‘overheated’ category of tumours. Through interrogation of our preclinical models of tumour control versus progression using advanced data analytic pipelines, we identified therapeutic targets that can enhance tumour elimination.

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KW - tailored therapies

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DO - 10.26182/sg5x-7w14

M3 - Doctoral Thesis

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Interrogating the functional diversity of type I interferons to generate tailored therapies for cancer

Abstract

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Research output

Directing the future breakthroughs in immunotherapy: The importance of a holistic approach to the tumour microenvironment

Cite this