International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents

Priyakumari Ganesh Parmar, H. Rob Taal, Nicholas J. Timpson, Elisabeth Thiering, Terho Lehtimaki, Marcella Marinelli, Penelope A. Lind, Laura D. Howe, Germaine Verwoert, Ville Aalto, Andre G. Uitterlinden, Laurent Briollais, Dave M. Evans, Margie J. Wright, John P. Newnham, John B. Whitfield, Leo-Pekka Lyytikainen, Fernando Rivadeneira, Dorrett I. Boomsma, Jorma Viikari & 19 others Matthew W. Gillman, Beate St Pourcain, Jouke-Jan Hottenga, Grant W. Montgomery, Albert Hofman, Mika Kahonen, Nicholas G. Martin, Martin D. Tobin, Ollie Raitakari, Jesus Vioque, Vincent W. V. Jaddoe, Marjo-Riita Jarvelin, Lawrence J. Beilin, Joachim Heinrich, Cornelia M. van Duijn, Craig E. Pennell, Debbie A. Lawlor, Lyle J. Palmer, Early Genetics Lifecourse

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    Background-Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.

    Methods and Results Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years), Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty (P=2.86x10(-8)) and rs872256 during puberty (P=8.67x10(-9)). Several single-nucleotide polymorphism clusters were also associated with childhood BP at P

    Conclusions-OurresultssuggestthatgeneticdeterminantsofBPactfromchildhood,developoverthelifecourse,andshowsomeevidence of age-specific effects.

    Original languageEnglish
    Pages (from-to)266-278
    Number of pages92
    JournalCirculation: Cardiovascular Genetics
    Volume9
    Issue number3
    Early online date11 Mar 2016
    DOIs
    Publication statusPublished - Jun 2016

    Cite this

    Parmar, Priyakumari Ganesh ; Taal, H. Rob ; Timpson, Nicholas J. ; Thiering, Elisabeth ; Lehtimaki, Terho ; Marinelli, Marcella ; Lind, Penelope A. ; Howe, Laura D. ; Verwoert, Germaine ; Aalto, Ville ; Uitterlinden, Andre G. ; Briollais, Laurent ; Evans, Dave M. ; Wright, Margie J. ; Newnham, John P. ; Whitfield, John B. ; Lyytikainen, Leo-Pekka ; Rivadeneira, Fernando ; Boomsma, Dorrett I. ; Viikari, Jorma ; Gillman, Matthew W. ; St Pourcain, Beate ; Hottenga, Jouke-Jan ; Montgomery, Grant W. ; Hofman, Albert ; Kahonen, Mika ; Martin, Nicholas G. ; Tobin, Martin D. ; Raitakari, Ollie ; Vioque, Jesus ; Jaddoe, Vincent W. V. ; Jarvelin, Marjo-Riita ; Beilin, Lawrence J. ; Heinrich, Joachim ; van Duijn, Cornelia M. ; Pennell, Craig E. ; Lawlor, Debbie A. ; Palmer, Lyle J. ; Early Genetics Lifecourse. / International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents. In: Circulation: Cardiovascular Genetics. 2016 ; Vol. 9, No. 3. pp. 266-278.
    @article{b32e4d06e2904c1e9f0b35e2a2595a3e,
    title = "International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents",
    abstract = "Background-Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.Methods and Results Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years), Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty (P=2.86x10(-8)) and rs872256 during puberty (P=8.67x10(-9)). Several single-nucleotide polymorphism clusters were also associated with childhood BP at PConclusions-OurresultssuggestthatgeneticdeterminantsofBPactfromchildhood,developoverthelifecourse,andshowsomeevidence of age-specific effects.",
    keywords = "blood pressure, children, genetic epidemiology, Genome-Wide Association Study, hypertension, prehypertension, CORONARY-ARTERY-DISEASE, VASCULAR ENDOTHELIAL-CELLS, GENE-CENTRIC METAANALYSIS, CANDIDATE GENES, IGA NEPHROPATHY, COMMON VARIANTS, ATHEROTHROMBOTIC STROKE, CARDIOVASCULAR RISK, PULSE PRESSURE, FUNCTIONAL SNP",
    author = "Parmar, {Priyakumari Ganesh} and Taal, {H. Rob} and Timpson, {Nicholas J.} and Elisabeth Thiering and Terho Lehtimaki and Marcella Marinelli and Lind, {Penelope A.} and Howe, {Laura D.} and Germaine Verwoert and Ville Aalto and Uitterlinden, {Andre G.} and Laurent Briollais and Evans, {Dave M.} and Wright, {Margie J.} and Newnham, {John P.} and Whitfield, {John B.} and Leo-Pekka Lyytikainen and Fernando Rivadeneira and Boomsma, {Dorrett I.} and Jorma Viikari and Gillman, {Matthew W.} and {St Pourcain}, Beate and Jouke-Jan Hottenga and Montgomery, {Grant W.} and Albert Hofman and Mika Kahonen and Martin, {Nicholas G.} and Tobin, {Martin D.} and Ollie Raitakari and Jesus Vioque and Jaddoe, {Vincent W. V.} and Marjo-Riita Jarvelin and Beilin, {Lawrence J.} and Joachim Heinrich and {van Duijn}, {Cornelia M.} and Pennell, {Craig E.} and Lawlor, {Debbie A.} and Palmer, {Lyle J.} and {Early Genetics Lifecourse}",
    year = "2016",
    month = "6",
    doi = "10.1161/CIRCGENETICS.115.001190",
    language = "English",
    volume = "9",
    pages = "266--278",
    journal = "Circulation-Cardiovascular Genetics",
    issn = "1942-325X",
    publisher = "Lippincott Williams & Wilkins",
    number = "3",

    }

    Parmar, PG, Taal, HR, Timpson, NJ, Thiering, E, Lehtimaki, T, Marinelli, M, Lind, PA, Howe, LD, Verwoert, G, Aalto, V, Uitterlinden, AG, Briollais, L, Evans, DM, Wright, MJ, Newnham, JP, Whitfield, JB, Lyytikainen, L-P, Rivadeneira, F, Boomsma, DI, Viikari, J, Gillman, MW, St Pourcain, B, Hottenga, J-J, Montgomery, GW, Hofman, A, Kahonen, M, Martin, NG, Tobin, MD, Raitakari, O, Vioque, J, Jaddoe, VWV, Jarvelin, M-R, Beilin, LJ, Heinrich, J, van Duijn, CM, Pennell, CE, Lawlor, DA, Palmer, LJ & Early Genetics Lifecourse 2016, 'International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents' Circulation: Cardiovascular Genetics, vol. 9, no. 3, pp. 266-278. https://doi.org/10.1161/CIRCGENETICS.115.001190

    International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents. / Parmar, Priyakumari Ganesh; Taal, H. Rob; Timpson, Nicholas J.; Thiering, Elisabeth; Lehtimaki, Terho; Marinelli, Marcella; Lind, Penelope A.; Howe, Laura D.; Verwoert, Germaine; Aalto, Ville; Uitterlinden, Andre G.; Briollais, Laurent; Evans, Dave M.; Wright, Margie J.; Newnham, John P.; Whitfield, John B.; Lyytikainen, Leo-Pekka; Rivadeneira, Fernando; Boomsma, Dorrett I.; Viikari, Jorma; Gillman, Matthew W.; St Pourcain, Beate; Hottenga, Jouke-Jan; Montgomery, Grant W.; Hofman, Albert; Kahonen, Mika; Martin, Nicholas G.; Tobin, Martin D.; Raitakari, Ollie; Vioque, Jesus; Jaddoe, Vincent W. V.; Jarvelin, Marjo-Riita; Beilin, Lawrence J.; Heinrich, Joachim; van Duijn, Cornelia M.; Pennell, Craig E.; Lawlor, Debbie A.; Palmer, Lyle J.; Early Genetics Lifecourse.

    In: Circulation: Cardiovascular Genetics, Vol. 9, No. 3, 06.2016, p. 266-278.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents

    AU - Parmar, Priyakumari Ganesh

    AU - Taal, H. Rob

    AU - Timpson, Nicholas J.

    AU - Thiering, Elisabeth

    AU - Lehtimaki, Terho

    AU - Marinelli, Marcella

    AU - Lind, Penelope A.

    AU - Howe, Laura D.

    AU - Verwoert, Germaine

    AU - Aalto, Ville

    AU - Uitterlinden, Andre G.

    AU - Briollais, Laurent

    AU - Evans, Dave M.

    AU - Wright, Margie J.

    AU - Newnham, John P.

    AU - Whitfield, John B.

    AU - Lyytikainen, Leo-Pekka

    AU - Rivadeneira, Fernando

    AU - Boomsma, Dorrett I.

    AU - Viikari, Jorma

    AU - Gillman, Matthew W.

    AU - St Pourcain, Beate

    AU - Hottenga, Jouke-Jan

    AU - Montgomery, Grant W.

    AU - Hofman, Albert

    AU - Kahonen, Mika

    AU - Martin, Nicholas G.

    AU - Tobin, Martin D.

    AU - Raitakari, Ollie

    AU - Vioque, Jesus

    AU - Jaddoe, Vincent W. V.

    AU - Jarvelin, Marjo-Riita

    AU - Beilin, Lawrence J.

    AU - Heinrich, Joachim

    AU - van Duijn, Cornelia M.

    AU - Pennell, Craig E.

    AU - Lawlor, Debbie A.

    AU - Palmer, Lyle J.

    AU - Early Genetics Lifecourse

    PY - 2016/6

    Y1 - 2016/6

    N2 - Background-Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.Methods and Results Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years), Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty (P=2.86x10(-8)) and rs872256 during puberty (P=8.67x10(-9)). Several single-nucleotide polymorphism clusters were also associated with childhood BP at PConclusions-OurresultssuggestthatgeneticdeterminantsofBPactfromchildhood,developoverthelifecourse,andshowsomeevidence of age-specific effects.

    AB - Background-Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.Methods and Results Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years), Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty (P=2.86x10(-8)) and rs872256 during puberty (P=8.67x10(-9)). Several single-nucleotide polymorphism clusters were also associated with childhood BP at PConclusions-OurresultssuggestthatgeneticdeterminantsofBPactfromchildhood,developoverthelifecourse,andshowsomeevidence of age-specific effects.

    KW - blood pressure

    KW - children

    KW - genetic epidemiology

    KW - Genome-Wide Association Study

    KW - hypertension

    KW - prehypertension

    KW - CORONARY-ARTERY-DISEASE

    KW - VASCULAR ENDOTHELIAL-CELLS

    KW - GENE-CENTRIC METAANALYSIS

    KW - CANDIDATE GENES

    KW - IGA NEPHROPATHY

    KW - COMMON VARIANTS

    KW - ATHEROTHROMBOTIC STROKE

    KW - CARDIOVASCULAR RISK

    KW - PULSE PRESSURE

    KW - FUNCTIONAL SNP

    U2 - 10.1161/CIRCGENETICS.115.001190

    DO - 10.1161/CIRCGENETICS.115.001190

    M3 - Article

    VL - 9

    SP - 266

    EP - 278

    JO - Circulation-Cardiovascular Genetics

    JF - Circulation-Cardiovascular Genetics

    SN - 1942-325X

    IS - 3

    ER -