International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents

Priyakumari Ganesh Parmar, H. Rob Taal, Nicholas J. Timpson, Elisabeth Thiering, Terho Lehtimaki, Marcella Marinelli, Penelope A. Lind, Laura D. Howe, Germaine Verwoert, Ville Aalto, Andre G. Uitterlinden, Laurent Briollais, Dave M. Evans, Margie J. Wright, John P. Newnham, John B. Whitfield, Leo-Pekka Lyytikainen, Fernando Rivadeneira, Dorrett I. Boomsma, Jorma ViikariMatthew W. Gillman, Beate St Pourcain, Jouke-Jan Hottenga, Grant W. Montgomery, Albert Hofman, Mika Kahonen, Nicholas G. Martin, Martin D. Tobin, Ollie Raitakari, Jesus Vioque, Vincent W. V. Jaddoe, Marjo-Riita Jarvelin, Lawrence J. Beilin, Joachim Heinrich, Cornelia M. van Duijn, Craig E. Pennell, Debbie A. Lawlor, Lyle J. Palmer, Early Genetics Lifecourse

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    Abstract

    Background-Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.

    Methods and Results Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years), Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty (P=2.86x10(-8)) and rs872256 during puberty (P=8.67x10(-9)). Several single-nucleotide polymorphism clusters were also associated with childhood BP at P

    Conclusions-OurresultssuggestthatgeneticdeterminantsofBPactfromchildhood,developoverthelifecourse,andshowsomeevidence of age-specific effects.

    Original languageEnglish
    Pages (from-to)266-278
    Number of pages92
    JournalCirculation: Cardiovascular Genetics
    Volume9
    Issue number3
    Early online date11 Mar 2016
    DOIs
    Publication statusPublished - Jun 2016

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