Projects per year
Background-Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.
Methods and Results Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years), Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty (P=2.86x10(-8)) and rs872256 during puberty (P=8.67x10(-9)). Several single-nucleotide polymorphism clusters were also associated with childhood BP at P
Conclusions-OurresultssuggestthatgeneticdeterminantsofBPactfromchildhood,developoverthelifecourse,andshowsomeevidence of age-specific effects.
31/12/08 → 31/12/11
403981: Childhood Precursors of Adult Cardiovascular Disease, Obesity and Diabetes- 16 Year Follow up of a Longitudinal Cohort
1/01/06 → 31/12/09