Projects per year
Background-Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.
Methods and Results Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years), Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty (P=2.86x10(-8)) and rs872256 during puberty (P=8.67x10(-9)). Several single-nucleotide polymorphism clusters were also associated with childhood BP at P
Conclusions-OurresultssuggestthatgeneticdeterminantsofBPactfromchildhood,developoverthelifecourse,andshowsomeevidence of age-specific effects.
|Number of pages||13|
|Journal||Circulation: Cardiovascular Genetics|
|Publication status||Published - 1 Jun 2016|
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- 4 Finished
A Genome Wide Search for Genes Underlying the Developmental Origins of Health and Disease
Pennell, C., Palmer, L., Beilin, L., Newnham, J., Lye, S. & Smith, G. D.
National Health & Medical Research Council NHMRC
31/12/08 → 31/12/11
403981: Childhood Precursors of Adult Cardiovascular Disease, Obesity and Diabetes- 16 Year Follow up of a Longitudinal Cohort
Beilin, L., Palmer, L., Oddy, W., Mori, T., Kendall, G. & Hands, B.
1/01/06 → 31/12/09
Determinants of Child Health and Development: Populations, Partnerships, Pathways and Prevention.
Stanley, F., De Klerk, N., Lehmann, D., Leonard, H., Zubrick, S., Silburn, S. & Bower, C.
1/01/05 → 31/12/09