International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents

Priyakumari Ganesh Parmar; H. Rob Taal; Nicholas J. Timpson; Elisabeth Thiering; Terho Lehtimaki; Marcella Marinelli; Penelope A. Lind; Laura D. Howe; Germaine Verwoert; Ville Aalto; Andre G. Uitterlinden; Laurent Briollais; Dave M. Evans; Margie J. Wright; John P. Newnham; John B. Whitfield; Leo-Pekka Lyytikainen; Fernando Rivadeneira; Dorrett I. Boomsma; Jorma Viikari; Matthew W. Gillman; Beate St Pourcain; Jouke-Jan Hottenga; Grant W. Montgomery; Albert Hofman; Mika Kahonen; Nicholas G. Martin; Martin D. Tobin; Ollie Raitakari; Jesus Vioque; Vincent W. V. Jaddoe; Marjo-Riita Jarvelin; Lawrence J. Beilin; Joachim Heinrich; Cornelia M. van Duijn; Craig E. Pennell; Debbie A. Lawlor; Lyle J. Palmer; Early Genetics Lifecourse

doi:10.1161/CIRCGENETICS.115.001190

International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents

Priyakumari Ganesh Parmar, H. Rob Taal, Nicholas J. Timpson, Elisabeth Thiering, Terho Lehtimaki, Marcella Marinelli, Penelope A. Lind, Laura D. Howe, Germaine Verwoert, Ville Aalto, Andre G. Uitterlinden, Laurent Briollais, Dave M. Evans, Margie J. Wright, John P. Newnham, John B. Whitfield, Leo-Pekka Lyytikainen, Fernando Rivadeneira, Dorrett I. Boomsma, Jorma ViikariMatthew W. Gillman, Beate St Pourcain, Jouke-Jan Hottenga, Grant W. Montgomery, Albert Hofman, Mika Kahonen, Nicholas G. Martin, Martin D. Tobin, Ollie Raitakari, Jesus Vioque, Vincent W. V. Jaddoe, Marjo-Riita Jarvelin, Lawrence J. Beilin, Joachim Heinrich, Cornelia M. van Duijn, Craig E. Pennell, Debbie A. Lawlor, Lyle J. Palmer, Early Genetics Lifecourse

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Abstract

Background-Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.

Methods and Results Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years), Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty (P=2.86x10(-8)) and rs872256 during puberty (P=8.67x10(-9)). Several single-nucleotide polymorphism clusters were also associated with childhood BP at P

Conclusions-OurresultssuggestthatgeneticdeterminantsofBPactfromchildhood,developoverthelifecourse,andshowsomeevidence of age-specific effects.

Original language	English
Pages (from-to)	266-278
Number of pages	13
Journal	Circulation: Cardiovascular Genetics
Volume	9
Issue number	3
DOIs	https://doi.org/10.1161/CIRCGENETICS.115.001190
Publication status	Published - 1 Jun 2016

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10.1161/CIRCGENETICS.115.001190

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279885/

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Parmar, P. G., Taal, H. R., Timpson, N. J., Thiering, E., Lehtimaki, T., Marinelli, M., Lind, P. A., Howe, L. D., Verwoert, G., Aalto, V., Uitterlinden, A. G., Briollais, L., Evans, D. M., Wright, M. J., Newnham, J. P., Whitfield, J. B., Lyytikainen, L.-P., Rivadeneira, F., Boomsma, D. I., ... Early Genetics Lifecourse (2016). International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents. Circulation: Cardiovascular Genetics, 9(3), 266-278. https://doi.org/10.1161/CIRCGENETICS.115.001190

@article{b32e4d06e2904c1e9f0b35e2a2595a3e,

title = "International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents",

abstract = "Background-Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.Methods and Results Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years), Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty (P=2.86x10(-8)) and rs872256 during puberty (P=8.67x10(-9)). Several single-nucleotide polymorphism clusters were also associated with childhood BP at PConclusions-OurresultssuggestthatgeneticdeterminantsofBPactfromchildhood,developoverthelifecourse,andshowsomeevidence of age-specific effects.",

keywords = "blood pressure, children, genetic epidemiology, Genome-Wide Association Study, hypertension, prehypertension, CORONARY-ARTERY-DISEASE, VASCULAR ENDOTHELIAL-CELLS, GENE-CENTRIC METAANALYSIS, CANDIDATE GENES, IGA NEPHROPATHY, COMMON VARIANTS, ATHEROTHROMBOTIC STROKE, CARDIOVASCULAR RISK, PULSE PRESSURE, FUNCTIONAL SNP",

author = "Parmar, {Priyakumari Ganesh} and Taal, {H. Rob} and Timpson, {Nicholas J.} and Elisabeth Thiering and Terho Lehtimaki and Marcella Marinelli and Lind, {Penelope A.} and Howe, {Laura D.} and Germaine Verwoert and Ville Aalto and Uitterlinden, {Andre G.} and Laurent Briollais and Evans, {Dave M.} and Wright, {Margie J.} and Newnham, {John P.} and Whitfield, {John B.} and Leo-Pekka Lyytikainen and Fernando Rivadeneira and Boomsma, {Dorrett I.} and Jorma Viikari and Gillman, {Matthew W.} and {St Pourcain}, Beate and Jouke-Jan Hottenga and Montgomery, {Grant W.} and Albert Hofman and Mika Kahonen and Martin, {Nicholas G.} and Tobin, {Martin D.} and Ollie Raitakari and Jesus Vioque and Jaddoe, {Vincent W. V.} and Marjo-Riita Jarvelin and Beilin, {Lawrence J.} and Joachim Heinrich and {van Duijn}, {Cornelia M.} and Pennell, {Craig E.} and Lawlor, {Debbie A.} and Palmer, {Lyle J.} and {Early Genetics Lifecourse}",

year = "2016",

month = jun,

day = "1",

doi = "10.1161/CIRCGENETICS.115.001190",

language = "English",

volume = "9",

pages = "266--278",

journal = "Circulation: Cardiovascular Genetics",

issn = "1942-325X",

publisher = "Lippincott Williams & Wilkins",

number = "3",

}

Parmar, PG, Taal, HR, Timpson, NJ, Thiering, E, Lehtimaki, T, Marinelli, M, Lind, PA, Howe, LD, Verwoert, G, Aalto, V, Uitterlinden, AG, Briollais, L, Evans, DM, Wright, MJ, Newnham, JP, Whitfield, JB, Lyytikainen, L-P, Rivadeneira, F, Boomsma, DI, Viikari, J, Gillman, MW, St Pourcain, B, Hottenga, J-J, Montgomery, GW, Hofman, A, Kahonen, M, Martin, NG, Tobin, MD, Raitakari, O, Vioque, J, Jaddoe, VWV, Jarvelin, M-R, Beilin, LJ, Heinrich, J, van Duijn, CM, Pennell, CE, Lawlor, DA, Palmer, LJ & Early Genetics Lifecourse 2016, 'International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents', Circulation: Cardiovascular Genetics, vol. 9, no. 3, pp. 266-278. https://doi.org/10.1161/CIRCGENETICS.115.001190

TY - JOUR

T1 - International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents

AU - Parmar, Priyakumari Ganesh

AU - Taal, H. Rob

AU - Timpson, Nicholas J.

AU - Thiering, Elisabeth

AU - Lehtimaki, Terho

AU - Marinelli, Marcella

AU - Lind, Penelope A.

AU - Howe, Laura D.

AU - Verwoert, Germaine

AU - Aalto, Ville

AU - Uitterlinden, Andre G.

AU - Briollais, Laurent

AU - Evans, Dave M.

AU - Wright, Margie J.

AU - Newnham, John P.

AU - Whitfield, John B.

AU - Lyytikainen, Leo-Pekka

AU - Rivadeneira, Fernando

AU - Boomsma, Dorrett I.

AU - Viikari, Jorma

AU - Gillman, Matthew W.

AU - St Pourcain, Beate

AU - Hottenga, Jouke-Jan

AU - Montgomery, Grant W.

AU - Hofman, Albert

AU - Kahonen, Mika

AU - Martin, Nicholas G.

AU - Tobin, Martin D.

AU - Raitakari, Ollie

AU - Vioque, Jesus

AU - Jaddoe, Vincent W. V.

AU - Jarvelin, Marjo-Riita

AU - Beilin, Lawrence J.

AU - Heinrich, Joachim

AU - van Duijn, Cornelia M.

AU - Pennell, Craig E.

AU - Lawlor, Debbie A.

AU - Palmer, Lyle J.

AU - Early Genetics Lifecourse

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Background-Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.Methods and Results Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years), Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty (P=2.86x10(-8)) and rs872256 during puberty (P=8.67x10(-9)). Several single-nucleotide polymorphism clusters were also associated with childhood BP at PConclusions-OurresultssuggestthatgeneticdeterminantsofBPactfromchildhood,developoverthelifecourse,andshowsomeevidence of age-specific effects.

AB - Background-Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.Methods and Results Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years), Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty (P=2.86x10(-8)) and rs872256 during puberty (P=8.67x10(-9)). Several single-nucleotide polymorphism clusters were also associated with childhood BP at PConclusions-OurresultssuggestthatgeneticdeterminantsofBPactfromchildhood,developoverthelifecourse,andshowsomeevidence of age-specific effects.

KW - blood pressure

KW - children

KW - genetic epidemiology

KW - Genome-Wide Association Study

KW - hypertension

KW - prehypertension

KW - CORONARY-ARTERY-DISEASE

KW - VASCULAR ENDOTHELIAL-CELLS

KW - GENE-CENTRIC METAANALYSIS

KW - CANDIDATE GENES

KW - IGA NEPHROPATHY

KW - COMMON VARIANTS

KW - ATHEROTHROMBOTIC STROKE

KW - CARDIOVASCULAR RISK

KW - PULSE PRESSURE

KW - FUNCTIONAL SNP

UR - http://www.scopus.com/inward/record.url?scp=84975682930&partnerID=8YFLogxK

U2 - 10.1161/CIRCGENETICS.115.001190

DO - 10.1161/CIRCGENETICS.115.001190

M3 - Article

C2 - 26969751

SN - 1942-325X

VL - 9

SP - 266

EP - 278

JO - Circulation: Cardiovascular Genetics

JF - Circulation: Cardiovascular Genetics

IS - 3

ER -

International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents

Abstract

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A Genome Wide Search for Genes Underlying the Developmental Origins of Health and Disease

403981: Childhood Precursors of Adult Cardiovascular Disease, Obesity and Diabetes- 16 Year Follow up of a Longitudinal Cohort

Determinants of Child Health and Development: Populations, Partnerships, Pathways and Prevention.

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International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents

Abstract

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Projects

A Genome Wide Search for Genes Underlying the Developmental Origins of Health and Disease

403981: Childhood Precursors of Adult Cardiovascular Disease, Obesity and Diabetes- 16 Year Follow up of a Longitudinal Cohort

Determinants of Child Health and Development: Populations, Partnerships, Pathways and Prevention.

Cite this