Interleukin-4 stimulates human monocytes to produce tissue-type plasminogen activator

P. H. Hart, D. R. Burgess, G. F. Vitti, J. A. Hamilton

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Tissue-type plasminogen activator (t-PA) is involved in the lysis of blood clots (fibrinolysis) and is used clinically for this purpose. Endothelial cells are one source of the t-PA present in blood. We report here that interleukin-4 (IL-4) (0.1 to 0.25 U/mL; 1 to 3 x 10-11 mol/L), but not interferon-γ (IFN-γ), elevates t-PA messenger (m)RNA expression and secretion of t-PA activity by human monocytes, with the maximum response at 2.5 U/mL. Supernatant t-PA activity was detected within three hours of exposure to IL-4 and maximum activity within six hours. Thus, IL-4 may control fibrin deposition at sites of inflammation during cell-mediated immune responses, as well as having a therapeutic role in thrombolysis.

Original languageEnglish
Pages (from-to)1222-1225
Number of pages4
JournalBlood
Volume74
Issue number4
Publication statusPublished - 1 Jan 1989
Externally publishedYes

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