Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

M. Eslam; A.M.A. Hashem; R. Leung; M. Romero-Gómez; T. Berg; G.J. Doré; H.L.K. Chan; W.L. Irving; D.A. Sheridan; M.L. Abate; Leon Adams; A. Mangia; M.D. Weltman; E. Bugianesi; U. Spengler; O.G.A. Shaker; J. Fischer; L.C. Mollison; W. Cheng; E.E. Powell; J. Nattermann; S.M. Riordan; D.J. Mcleod; N.J. Armstrong; M.W.W. Douglas; C. Liddle; D.R. Booth; J. George; G. Ahlenstiel; J.A. Ampuero; M.F. Bassendine; V.W.S. Wong; C. Rosso; R. White; L. Mezzabotta; V. Suppiah; M. Michalk; B. Malik; G.V. Matthews; T.L. Applegate; J. Grebely; V. Fragomeli; J.R. Jonsson; R. Santaro

doi:10.1038/ncomms7422

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

M. Eslam, A.M.A. Hashem, R. Leung, M. Romero-Gómez, T. Berg, G.J. Doré, H.L.K. Chan, W.L. Irving, D.A. Sheridan, M.L. Abate, Leon Adams, A. Mangia, M.D. Weltman, E. Bugianesi, U. Spengler, O.G.A. Shaker, J. Fischer, L.C. Mollison, W. Cheng, E.E. PowellJ. Nattermann, S.M. Riordan, D.J. Mcleod, N.J. Armstrong, M.W.W. Douglas, C. Liddle, D.R. Booth, J. George, G. Ahlenstiel, J.A. Ampuero, M.F. Bassendine, V.W.S. Wong, C. Rosso, R. White, L. Mezzabotta, V. Suppiah, M. Michalk, B. Malik, G.V. Matthews, T.L. Applegate, J. Grebely, V. Fragomeli, J.R. Jonsson, R. Santaro

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Abstract

© 2015 Macmillan Publishers Limited. All rights reserved. Tissue fibrosis is a core pathologic process that contributes to mortality in ∼45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis. In CHC, those with rs12979860CC also have greater stage-constant and stage-specific fibrosis progression rates (P

Original language	English
Article number	6422
Number of pages	10
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms7422
Publication status	Published - 5 Mar 2015

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Eslam, M., Hashem, A. M. A., Leung, R., Romero-Gómez, M., Berg, T., Doré, G. J., Chan, H. L. K., Irving, W. L., Sheridan, D. A., Abate, M. L., Adams, L., Mangia, A., Weltman, M. D., Bugianesi, E., Spengler, U., Shaker, O. G. A., Fischer, J., Mollison, L. C., Cheng, W., ... Santaro, R. (2015). Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease. Nature Communications, 6, [6422]. https://doi.org/10.1038/ncomms7422

Eslam, M. ; Hashem, A.M.A. ; Leung, R. ; Romero-Gómez, M. ; Berg, T. ; Doré, G.J. ; Chan, H.L.K. ; Irving, W.L. ; Sheridan, D.A. ; Abate, M.L. ; Adams, Leon ; Mangia, A. ; Weltman, M.D. ; Bugianesi, E. ; Spengler, U. ; Shaker, O.G.A. ; Fischer, J. ; Mollison, L.C. ; Cheng, W. ; Powell, E.E. ; Nattermann, J. ; Riordan, S.M. ; Mcleod, D.J. ; Armstrong, N.J. ; Douglas, M.W.W. ; Liddle, C. ; Booth, D.R. ; George, J. ; Ahlenstiel, G. ; Ampuero, J.A. ; Bassendine, M.F. ; Wong, V.W.S. ; Rosso, C. ; White, R. ; Mezzabotta, L. ; Suppiah, V. ; Michalk, M. ; Malik, B. ; Matthews, G.V. ; Applegate, T.L. ; Grebely, J. ; Fragomeli, V. ; Jonsson, J.R. ; Santaro, R. / Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease. In: Nature Communications. 2015 ; Vol. 6.

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abstract = "{\textcopyright} 2015 Macmillan Publishers Limited. All rights reserved. Tissue fibrosis is a core pathologic process that contributes to mortality in ∼45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis. In CHC, those with rs12979860CC also have greater stage-constant and stage-specific fibrosis progression rates (P",

author = "M. Eslam and A.M.A. Hashem and R. Leung and M. Romero-G{\'o}mez and T. Berg and G.J. Dor{\'e} and H.L.K. Chan and W.L. Irving and D.A. Sheridan and M.L. Abate and Leon Adams and A. Mangia and M.D. Weltman and E. Bugianesi and U. Spengler and O.G.A. Shaker and J. Fischer and L.C. Mollison and W. Cheng and E.E. Powell and J. Nattermann and S.M. Riordan and D.J. Mcleod and N.J. Armstrong and M.W.W. Douglas and C. Liddle and D.R. Booth and J. George and G. Ahlenstiel and J.A. Ampuero and M.F. Bassendine and V.W.S. Wong and C. Rosso and R. White and L. Mezzabotta and V. Suppiah and M. Michalk and B. Malik and G.V. Matthews and T.L. Applegate and J. Grebely and V. Fragomeli and J.R. Jonsson and R. Santaro",

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Eslam, M, Hashem, AMA, Leung, R, Romero-Gómez, M, Berg, T, Doré, GJ, Chan, HLK, Irving, WL, Sheridan, DA, Abate, ML, Adams, L, Mangia, A, Weltman, MD, Bugianesi, E, Spengler, U, Shaker, OGA, Fischer, J, Mollison, LC, Cheng, W, Powell, EE, Nattermann, J, Riordan, SM, Mcleod, DJ, Armstrong, NJ, Douglas, MWW, Liddle, C, Booth, DR, George, J, Ahlenstiel, G, Ampuero, JA, Bassendine, MF, Wong, VWS, Rosso, C, White, R, Mezzabotta, L, Suppiah, V, Michalk, M, Malik, B, Matthews, GV, Applegate, TL, Grebely, J, Fragomeli, V, Jonsson, JR & Santaro, R 2015, 'Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease', Nature Communications, vol. 6, 6422. https://doi.org/10.1038/ncomms7422

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease. / Eslam, M.; Hashem, A.M.A.; Leung, R.; Romero-Gómez, M.; Berg, T.; Doré, G.J.; Chan, H.L.K.; Irving, W.L.; Sheridan, D.A.; Abate, M.L.; Adams, Leon; Mangia, A.; Weltman, M.D.; Bugianesi, E.; Spengler, U.; Shaker, O.G.A.; Fischer, J.; Mollison, L.C.; Cheng, W.; Powell, E.E.; Nattermann, J.; Riordan, S.M.; Mcleod, D.J.; Armstrong, N.J.; Douglas, M.W.W.; Liddle, C.; Booth, D.R.; George, J.; Ahlenstiel, G.; Ampuero, J.A.; Bassendine, M.F.; Wong, V.W.S.; Rosso, C.; White, R.; Mezzabotta, L.; Suppiah, V.; Michalk, M.; Malik, B.; Matthews, G.V.; Applegate, T.L.; Grebely, J.; Fragomeli, V.; Jonsson, J.R.; Santaro, R.

In: Nature Communications, Vol. 6, 6422, 05.03.2015.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

AU - Eslam, M.

AU - Hashem, A.M.A.

AU - Leung, R.

AU - Romero-Gómez, M.

AU - Berg, T.

AU - Doré, G.J.

AU - Chan, H.L.K.

AU - Irving, W.L.

AU - Sheridan, D.A.

AU - Abate, M.L.

AU - Adams, Leon

AU - Mangia, A.

AU - Weltman, M.D.

AU - Bugianesi, E.

AU - Spengler, U.

AU - Shaker, O.G.A.

AU - Fischer, J.

AU - Mollison, L.C.

AU - Cheng, W.

AU - Powell, E.E.

AU - Nattermann, J.

AU - Riordan, S.M.

AU - Mcleod, D.J.

AU - Armstrong, N.J.

AU - Douglas, M.W.W.

AU - Liddle, C.

AU - Booth, D.R.

AU - George, J.

AU - Ahlenstiel, G.

AU - Ampuero, J.A.

AU - Bassendine, M.F.

AU - Wong, V.W.S.

AU - Rosso, C.

AU - White, R.

AU - Mezzabotta, L.

AU - Suppiah, V.

AU - Michalk, M.

AU - Malik, B.

AU - Matthews, G.V.

AU - Applegate, T.L.

AU - Grebely, J.

AU - Fragomeli, V.

AU - Jonsson, J.R.

AU - Santaro, R.

PY - 2015/3/5

Y1 - 2015/3/5

N2 - © 2015 Macmillan Publishers Limited. All rights reserved. Tissue fibrosis is a core pathologic process that contributes to mortality in ∼45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis. In CHC, those with rs12979860CC also have greater stage-constant and stage-specific fibrosis progression rates (P

AB - © 2015 Macmillan Publishers Limited. All rights reserved. Tissue fibrosis is a core pathologic process that contributes to mortality in ∼45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis. In CHC, those with rs12979860CC also have greater stage-constant and stage-specific fibrosis progression rates (P

U2 - 10.1038/ncomms7422

DO - 10.1038/ncomms7422

M3 - Article

C2 - 25740255

VL - 6

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 6422

ER -