Interferon-γ Response by Peripheral Blood Mononuclear Cells to Hepatitis C Virus Core Antigen Is Reduced in Patients with Liver Fibrosis

M.W. Watson, A. Jaksic, Patricia Price, W. Cheng, M. Mcinerney, Martyn French, S. Fisher, S. Lee, J.P. Flexman

Research output: Contribution to journalArticlepeer-review

10 Citations (Web of Science)

Abstract

Liver fibrosis was correlated with immunological parameters. Peripheral blood mononuclear cells ( PBMCs) from patients with low fibrosis scores had fewer interferon ( IFN) -gamma - producing cells than did patients with higher fibrosis scores, when stimulated with hepatitis C virus ( HCV) core antigen. Irrespective of liver fibrosis score, cells from all cytomegalovirus ( CMV) - seropositive patients had similar IFN - g responses, when stimulated by CMV antigen, so patients with fibrosis did not have a broad- spectrum immunodeficiency. IFN- gamma response by PBMCs to HCV core antigen may provide a useful marker of the severity of liver disease in patients with hepatitis C.
Original languageEnglish
Pages (from-to)1533-1536
Number of pages4
JournalJournal of Infectious Diseases
Volume188
Issue number10
DOIs
Publication statusPublished - 2003

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