Interactions Between Apo E and Amyloid Beta and their Relationship to Nutriproteomics and Neurodegeneration

Proteomics has advanced and identified various plasma proteins that may be involved in the nature of the lesions in the Alzheimer’s Disease (AD) brain. Interactions of two important proteins apolipoprotein E and amyloid beta are amongst the many Alzheimer’s disease candidate proteins that have been identified. The role of these two proteins has been shown in Alzheimer’s disease with effects by diet and nutriproteomics (protein/lipids/carbohydrate) on the plasma clearance of amyloid beta. The specific role of proteins and lipoproteins and their effects on hepatic amyloid beta clearance is important to brain amyloidosis. Oxidative stress induced by high cholesterol diets can cause electrostatic alterations in amyloid oligomers and oxidized lipids with alterations in liver function and effects on the central nervous system. In Alzheimer’s disease, the blood brain barrier is abnormal with leakage of proteins and oxidized lipids into the plasma of Alzheimer’s disease individuals. Hepatic acute phase proteins induced by inflammation and oxidative stress in health conditions such as obesity and diabetes have important roles in anti-amyloidogenic or amyloidogenic roles associated with the pathophysiology of Alzheimer’s disease. Proteomics seeks to identify modulations in protein structure and protein: protein interactions to improve the understanding of the peripheral metabolism of Aβ that reduce brain amyloid beta levels.
REFERENCE:
Interactions Between Apo E and Amyloid Beta and their Relationship to Nutriproteomics and Neurodegeneration. Current Proteomics, 2014 11, 173-183.