Interaction of some cardiovascular drugs with bovine serum albumin at physiological conditions using glassy carbon electrode: A new approach

Hadi Afsharan, Mohammad Hasanzadeh, Nasrin Shadjou, Abolghasem Jouyban

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

In this report, for the first time, the non-modified glassy carbon electrode was used for detection of cardiovascular drug interaction with bovine serum albumin (BSA). These interactions were tested at physiological conditions (T = 37 °C and pH = 7.4 phosphate buffer solution) in different incubation times (0-4 h) by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and square wave voltammetry (SWV). The applications of DPV for quantitative investigation of some cardiovascular drug interaction with BSA (as a model of serum albumin proteins) were discussed. The herein described approach is expected to promote the exploitation of electrochemically-based methods for the study of drug-serum albumin protein interaction which is necessary in biochemical and biosensing studies. This report may open a new window to application of electrochemical sensors towards interactions of cardiovascular drugs with BSA and human serum albumin (HAS) in the near future.

Original languageEnglish
Pages (from-to)97-108
Number of pages12
JournalMaterials Science and Engineering C
Volume65
DOIs
Publication statusPublished - 1 Aug 2016
Externally publishedYes

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