INTERACTION OF AMILORIDE WITH RAT PAROTID MUSCARINIC AND ALPHA-ADRENERGIC RECEPTORS

JP DEHAYE, V. VERHASSELT

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

1. In rat parotid acini, amiloride inhibited the secretion of amylase and the efflux of calcium and rubidium in response to carbamylcholine and to norepinephrine.

2. Amiloride competitively inhibited the binding of [H-3]N-methylscopolamine and [H-3] is thus a competitive antagonist of muscarinic and norepinephrine alpha-adrenergic receptors.

3. Amiloride did not affect the response to substance P with respect to secretion or ion movements.

4. Thus the Na+/H+ antiporter is not involved in the short-term regulation of amylase secretion and calcium and potassium movements in rat parotid gland function.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalGeneral Pharmacology
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 1995

Cite this

@article{c3f03ca95af945b988c557e34aea11e5,
title = "INTERACTION OF AMILORIDE WITH RAT PAROTID MUSCARINIC AND ALPHA-ADRENERGIC RECEPTORS",
abstract = "1. In rat parotid acini, amiloride inhibited the secretion of amylase and the efflux of calcium and rubidium in response to carbamylcholine and to norepinephrine.2. Amiloride competitively inhibited the binding of [H-3]N-methylscopolamine and [H-3] is thus a competitive antagonist of muscarinic and norepinephrine alpha-adrenergic receptors.3. Amiloride did not affect the response to substance P with respect to secretion or ion movements.4. Thus the Na+/H+ antiporter is not involved in the short-term regulation of amylase secretion and calcium and potassium movements in rat parotid gland function.",
keywords = "AMYLASE, CARBAMYLCHOLINE, EPINEPHRINE, SUBSTANCE P, NA+/H+ ANTIPORTER, PROTEIN KINASE-C, NA+/H+ EXCHANGE, ACINAR-CELLS, SUBSTANCE-P, ALPHA-2-ADRENERGIC RECEPTORS, INTRACELLULAR CALCIUM, SALIVARY SECRETION, ACTIVATION, STIMULATION, MECHANISMS",
author = "JP DEHAYE and V. VERHASSELT",
year = "1995",
month = "1",
doi = "10.1016/0306-3623(94)00153-E",
language = "English",
volume = "26",
pages = "155--159",
journal = "General Pharmacology",
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publisher = "Academic Press",
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INTERACTION OF AMILORIDE WITH RAT PAROTID MUSCARINIC AND ALPHA-ADRENERGIC RECEPTORS. / DEHAYE, JP; VERHASSELT, V.

In: General Pharmacology, Vol. 26, No. 1, 01.1995, p. 155-159.

Research output: Contribution to journalArticle

TY - JOUR

T1 - INTERACTION OF AMILORIDE WITH RAT PAROTID MUSCARINIC AND ALPHA-ADRENERGIC RECEPTORS

AU - DEHAYE, JP

AU - VERHASSELT, V.

PY - 1995/1

Y1 - 1995/1

N2 - 1. In rat parotid acini, amiloride inhibited the secretion of amylase and the efflux of calcium and rubidium in response to carbamylcholine and to norepinephrine.2. Amiloride competitively inhibited the binding of [H-3]N-methylscopolamine and [H-3] is thus a competitive antagonist of muscarinic and norepinephrine alpha-adrenergic receptors.3. Amiloride did not affect the response to substance P with respect to secretion or ion movements.4. Thus the Na+/H+ antiporter is not involved in the short-term regulation of amylase secretion and calcium and potassium movements in rat parotid gland function.

AB - 1. In rat parotid acini, amiloride inhibited the secretion of amylase and the efflux of calcium and rubidium in response to carbamylcholine and to norepinephrine.2. Amiloride competitively inhibited the binding of [H-3]N-methylscopolamine and [H-3] is thus a competitive antagonist of muscarinic and norepinephrine alpha-adrenergic receptors.3. Amiloride did not affect the response to substance P with respect to secretion or ion movements.4. Thus the Na+/H+ antiporter is not involved in the short-term regulation of amylase secretion and calcium and potassium movements in rat parotid gland function.

KW - AMYLASE

KW - CARBAMYLCHOLINE

KW - EPINEPHRINE

KW - SUBSTANCE P

KW - NA+/H+ ANTIPORTER

KW - PROTEIN KINASE-C

KW - NA+/H+ EXCHANGE

KW - ACINAR-CELLS

KW - SUBSTANCE-P

KW - ALPHA-2-ADRENERGIC RECEPTORS

KW - INTRACELLULAR CALCIUM

KW - SALIVARY SECRETION

KW - ACTIVATION

KW - STIMULATION

KW - MECHANISMS

U2 - 10.1016/0306-3623(94)00153-E

DO - 10.1016/0306-3623(94)00153-E

M3 - Article

VL - 26

SP - 155

EP - 159

JO - General Pharmacology

JF - General Pharmacology

SN - 1537-1891

IS - 1

ER -