Intake of specific carotenoids and the risk of epithelial ovarian cancer

Min Zhang, D'Arcy Holman, C.W. Binns

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

There has been considerable interest in the role of carotenoids in the chemoprevention of cancer. However, few studies have examined the association between intake of specific carotenoids and the risk of epithelial ovarian cancer and the results for carotenoids have been inconclusive. To investigate whether the intake of alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein and zeaxanthin, and lycopene is inversely associated with ovarian cancer risk, a case-control study was conducted in China during 1999-2000. The cases were 254 patients with histologically confirmed epithelial ovarian cancer and 652 age-matched controls were randomly recruited during the same period. Habitual dietary intake and lifestyle were collected by face-to-face interview using a validated and reliable FFQ. The US Department of Agriculture nutrient composition database was used to calculate the intake of specific carotenoids. Unconditional logistic regression analyses were used to estimate OR and 95 % Cl, accounting for age, locality, education, BMI, smoking, tea drinking, parity, oral contraceptive use, hormone replacement therapy, menopausal status, family history of ovarian cancer, physical activity and energy intake. Compared with the highest v. the lowest quartile of intake, the adjusted OR were 0 center dot 39 (95 % Cl 0 center dot 23, 0 center dot 66) for alpha-carotene, 0 center dot 51 (95 % Cl 0 center dot 31, 0 center dot 84) for beta-carotene, 0 center dot 51 (95 % CI 0 center dot 31, 0 center dot 83) for beta-cryptoxanthin, 0 center dot 45 (0 center dot 27, 0.76) for lutein and zeaxanthin, and 0 center dot 33 (95 % Cl 0 center dot 20, 0 center dot 56) for total carotenoids, with statistically significant tests for trend. It is concluded that a higher intake of carotenoids can reduce the risk of epithelial ovarian cancer.
Original languageEnglish
Pages (from-to)187-193
JournalBritish Journal of Nutrition
Volume98
Issue number1
DOIs
Publication statusPublished - 2007

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