Instrument performance in bone density testing at five Australian centres

K.M. Khan, S.L. Henzell, C. Broderick, Richard Prince, A. Saul, J. Lomman, J.D. Wark

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Aims: To assess the in vitro precision and accuracy of bone mineral densitometry (BMD) within and between locations at five Australian centres.Methods: Using a multicentre reliability study the accuracy and short-and long-term precision of dual-energy X-ray absorptiometry (DXA) in vitro was compared on five instruments. Measures were performed using pencil beam mode on four Hologic QDR-2000 densitometers and one Hologic QDR-1000/W (Hologic Inc, Waltham, MA).Results: Short-term precision of bone mineral density measurement was less than 0.5% for spine phantoms (n=10 for each centre, mean intrasite coefficient of variation [CV] 0.39+/-0.09% [SD]) and for hip phantoms (n=10 for each centre, mean intrasite coefficient of variation [CV] 0.34+/-0.10% [SD]). Between-centre measurement (n=10 for each phantom) of a single spine phantom and a single hip phantom (specified mineral contents - 58.5 g and 38.6 g, respectively) revealed ranges of bone mineral content of 57.7-58.1 g (all-point CV=0.52%) and 37.1-37.8 g (all-point CV=0.70%), respectively. When results from pairs of machines were compared there were statistically different mean BMD results for the majority of the ten possible pairings for both spine and hip measurements. Each study centre measured in vitro stability of phantom BMD measurements over a one year period (n=45-283 median 157 for spine; and n=0-262, median 38, for hip); CVs ranged from 0.38 to 0.53% for the spine measurements and from 0.38 to 0.54% for the hip measurements. The mean all-point accuracy of the spine phantom measurements was 99.1% and the hip phantom measurements was 96.7%.Conclusions: Across a number of instruments DXA demonstrates in vitro all-point precision of 0.5% for the spine phantom and 0.7% for the hip phantom. The instrument demonstrates accuracy of greater than 99% at the spine and 96% at the hip. This finding has clinical, research and quality control implications.
    Original languageEnglish
    Pages (from-to)526-530
    JournalAustralian and New Zealand Journal of Medicine
    Volume27
    Issue number5
    DOIs
    Publication statusPublished - 1997

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    Bone Density
    Hip
    Spine
    Minerals
    Densitometry
    Photon Absorptiometry
    Bone and Bones
    Quality Control
    Multicenter Studies
    In Vitro Techniques
    Research

    Cite this

    Khan, K.M. ; Henzell, S.L. ; Broderick, C. ; Prince, Richard ; Saul, A. ; Lomman, J. ; Wark, J.D. / Instrument performance in bone density testing at five Australian centres. In: Australian and New Zealand Journal of Medicine. 1997 ; Vol. 27, No. 5. pp. 526-530.
    @article{b63edd5c87dd49e3931a631a01c6f1d9,
    title = "Instrument performance in bone density testing at five Australian centres",
    abstract = "Aims: To assess the in vitro precision and accuracy of bone mineral densitometry (BMD) within and between locations at five Australian centres.Methods: Using a multicentre reliability study the accuracy and short-and long-term precision of dual-energy X-ray absorptiometry (DXA) in vitro was compared on five instruments. Measures were performed using pencil beam mode on four Hologic QDR-2000 densitometers and one Hologic QDR-1000/W (Hologic Inc, Waltham, MA).Results: Short-term precision of bone mineral density measurement was less than 0.5{\%} for spine phantoms (n=10 for each centre, mean intrasite coefficient of variation [CV] 0.39+/-0.09{\%} [SD]) and for hip phantoms (n=10 for each centre, mean intrasite coefficient of variation [CV] 0.34+/-0.10{\%} [SD]). Between-centre measurement (n=10 for each phantom) of a single spine phantom and a single hip phantom (specified mineral contents - 58.5 g and 38.6 g, respectively) revealed ranges of bone mineral content of 57.7-58.1 g (all-point CV=0.52{\%}) and 37.1-37.8 g (all-point CV=0.70{\%}), respectively. When results from pairs of machines were compared there were statistically different mean BMD results for the majority of the ten possible pairings for both spine and hip measurements. Each study centre measured in vitro stability of phantom BMD measurements over a one year period (n=45-283 median 157 for spine; and n=0-262, median 38, for hip); CVs ranged from 0.38 to 0.53{\%} for the spine measurements and from 0.38 to 0.54{\%} for the hip measurements. The mean all-point accuracy of the spine phantom measurements was 99.1{\%} and the hip phantom measurements was 96.7{\%}.Conclusions: Across a number of instruments DXA demonstrates in vitro all-point precision of 0.5{\%} for the spine phantom and 0.7{\%} for the hip phantom. The instrument demonstrates accuracy of greater than 99{\%} at the spine and 96{\%} at the hip. This finding has clinical, research and quality control implications.",
    author = "K.M. Khan and S.L. Henzell and C. Broderick and Richard Prince and A. Saul and J. Lomman and J.D. Wark",
    year = "1997",
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    Instrument performance in bone density testing at five Australian centres. / Khan, K.M.; Henzell, S.L.; Broderick, C.; Prince, Richard; Saul, A.; Lomman, J.; Wark, J.D.

    In: Australian and New Zealand Journal of Medicine, Vol. 27, No. 5, 1997, p. 526-530.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Instrument performance in bone density testing at five Australian centres

    AU - Khan, K.M.

    AU - Henzell, S.L.

    AU - Broderick, C.

    AU - Prince, Richard

    AU - Saul, A.

    AU - Lomman, J.

    AU - Wark, J.D.

    PY - 1997

    Y1 - 1997

    N2 - Aims: To assess the in vitro precision and accuracy of bone mineral densitometry (BMD) within and between locations at five Australian centres.Methods: Using a multicentre reliability study the accuracy and short-and long-term precision of dual-energy X-ray absorptiometry (DXA) in vitro was compared on five instruments. Measures were performed using pencil beam mode on four Hologic QDR-2000 densitometers and one Hologic QDR-1000/W (Hologic Inc, Waltham, MA).Results: Short-term precision of bone mineral density measurement was less than 0.5% for spine phantoms (n=10 for each centre, mean intrasite coefficient of variation [CV] 0.39+/-0.09% [SD]) and for hip phantoms (n=10 for each centre, mean intrasite coefficient of variation [CV] 0.34+/-0.10% [SD]). Between-centre measurement (n=10 for each phantom) of a single spine phantom and a single hip phantom (specified mineral contents - 58.5 g and 38.6 g, respectively) revealed ranges of bone mineral content of 57.7-58.1 g (all-point CV=0.52%) and 37.1-37.8 g (all-point CV=0.70%), respectively. When results from pairs of machines were compared there were statistically different mean BMD results for the majority of the ten possible pairings for both spine and hip measurements. Each study centre measured in vitro stability of phantom BMD measurements over a one year period (n=45-283 median 157 for spine; and n=0-262, median 38, for hip); CVs ranged from 0.38 to 0.53% for the spine measurements and from 0.38 to 0.54% for the hip measurements. The mean all-point accuracy of the spine phantom measurements was 99.1% and the hip phantom measurements was 96.7%.Conclusions: Across a number of instruments DXA demonstrates in vitro all-point precision of 0.5% for the spine phantom and 0.7% for the hip phantom. The instrument demonstrates accuracy of greater than 99% at the spine and 96% at the hip. This finding has clinical, research and quality control implications.

    AB - Aims: To assess the in vitro precision and accuracy of bone mineral densitometry (BMD) within and between locations at five Australian centres.Methods: Using a multicentre reliability study the accuracy and short-and long-term precision of dual-energy X-ray absorptiometry (DXA) in vitro was compared on five instruments. Measures were performed using pencil beam mode on four Hologic QDR-2000 densitometers and one Hologic QDR-1000/W (Hologic Inc, Waltham, MA).Results: Short-term precision of bone mineral density measurement was less than 0.5% for spine phantoms (n=10 for each centre, mean intrasite coefficient of variation [CV] 0.39+/-0.09% [SD]) and for hip phantoms (n=10 for each centre, mean intrasite coefficient of variation [CV] 0.34+/-0.10% [SD]). Between-centre measurement (n=10 for each phantom) of a single spine phantom and a single hip phantom (specified mineral contents - 58.5 g and 38.6 g, respectively) revealed ranges of bone mineral content of 57.7-58.1 g (all-point CV=0.52%) and 37.1-37.8 g (all-point CV=0.70%), respectively. When results from pairs of machines were compared there were statistically different mean BMD results for the majority of the ten possible pairings for both spine and hip measurements. Each study centre measured in vitro stability of phantom BMD measurements over a one year period (n=45-283 median 157 for spine; and n=0-262, median 38, for hip); CVs ranged from 0.38 to 0.53% for the spine measurements and from 0.38 to 0.54% for the hip measurements. The mean all-point accuracy of the spine phantom measurements was 99.1% and the hip phantom measurements was 96.7%.Conclusions: Across a number of instruments DXA demonstrates in vitro all-point precision of 0.5% for the spine phantom and 0.7% for the hip phantom. The instrument demonstrates accuracy of greater than 99% at the spine and 96% at the hip. This finding has clinical, research and quality control implications.

    U2 - 10.1111/j.1445-5994.1997.tb00959.x

    DO - 10.1111/j.1445-5994.1997.tb00959.x

    M3 - Article

    VL - 27

    SP - 526

    EP - 530

    JO - Australian & New Zealand Journal of Medicine

    JF - Australian & New Zealand Journal of Medicine

    SN - 0004-8291

    IS - 5

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