Innate Immune Response of Airway Epithelial Cells from Children with Cystic Fibrosis to Rhinovirus Infection

Kak-Ming Ling

doi:10.26182/2pwd-5774

Innate Immune Response of Airway Epithelial Cells from Children with Cystic Fibrosis to Rhinovirus Infection

Kak-Ming Ling

UWA Medical School

Research output: Thesis › Doctoral Thesis

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Abstract

A common cold virus (rhinovirus) infection in young children with CF can cause more severe impacts, such as hospitalisation, decline in lung function and excessive mucus production. Using samples from children with and without CF, this thesis found a more complex global gene signature in children with CF in response to RV infection, including inflammation and mucin production. This was validated using a 3D model of the airway which also found that the mucus produced by CF lung cells was chemically different from those produced by non-CF lung cells. Future work aims to develop therapeutic interventions targeting the identified pathways.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Stick, Stephen, Supervisor Kicic, Anthony, Supervisor Lassmann, Timo, Supervisor Garratt, Luke, Supervisor Laing, Ingrid, Supervisor
Award date	29 Jun 2021
DOIs	https://doi.org/10.26182/2pwd-5774
Publication status	Unpublished - 2021

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10.26182/2pwd-5774

THESIS - DOCTOR OF PHILOSOPHY - LING, Kak Ming - 2021
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Cite this

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abstract = "A common cold virus (rhinovirus) infection in young children with CF can cause more severe impacts, such as hospitalisation, decline in lung function and excessive mucus production. Using samples from children with and without CF, this thesis found a more complex global gene signature in children with CF in response to RV infection, including inflammation and mucin production. This was validated using a 3D model of the airway which also found that the mucus produced by CF lung cells was chemically different from those produced by non-CF lung cells. Future work aims to develop therapeutic interventions targeting the identified pathways. ",

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AB - A common cold virus (rhinovirus) infection in young children with CF can cause more severe impacts, such as hospitalisation, decline in lung function and excessive mucus production. Using samples from children with and without CF, this thesis found a more complex global gene signature in children with CF in response to RV infection, including inflammation and mucin production. This was validated using a 3D model of the airway which also found that the mucus produced by CF lung cells was chemically different from those produced by non-CF lung cells. Future work aims to develop therapeutic interventions targeting the identified pathways.

KW - cystic fibrosis

KW - mucin

KW - Airway epithelial cells

KW - Rhinovirus

KW - Transcriptomic

U2 - 10.26182/2pwd-5774

DO - 10.26182/2pwd-5774

M3 - Doctoral Thesis

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Innate Immune Response of Airway Epithelial Cells from Children with Cystic Fibrosis to Rhinovirus Infection

Abstract

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