Injury and Inflammation from Resuscitation of the Preterm Infant

Alan Jobe, N. Hillman, Graeme Polglase, B.W. Kramer, S. Kallapur, Jane Pillow

Research output: Contribution to journalArticlepeer-review

140 Citations (Scopus)


We review information about how the preterm lung can be injured with the initiation of mechanical ventilation at birth. Although multiple variables such as pressure, tidal volume, positive end expiratory pressure, and the gas used for ventilation may contribute to the injury, the relative contribution of each is not known. Recent studies demonstrate that injury caused by initial high tidal volume is amplified by subsequent mechanical ventilation. A model for gas inflation of the fluid-filled lung may explain why even low tidal volumes may injure the preterm lung, and why the injury may initially occur to the small airways. Ventilation strategies that minimize injury need to be developed.Copyright © 2008 S. Karger AG, Basel
Original languageEnglish
Pages (from-to)190-196
Issue number3
Publication statusPublished - 2008


Dive into the research topics of 'Injury and Inflammation from Resuscitation of the Preterm Infant'. Together they form a unique fingerprint.

Cite this