Inhibition of neurosphere proliferation by IFNγ but not IFNβ is coupled to neuronal differentiation

Maggie G. Lum, E. Croze, C. Wagner, S. McLenachan, B. Mitrovic, A. M. Turnley

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Interferons are produced following neural damage as part of the inflammatory response and may thus affect neural stem cell function. We compared the effects of interferon-γ and interferon-β on the proliferation and differentiation of adult murine neural progenitors. Both interferons inhibited neurosphere proliferation due to cell cycle arrest in G1 but only interferon-γ induced neuronal differentiation. Both interferons induced differential phosphorylation of STAT proteins and a modest and late upregulation of the cell cycle regulator p27 but not several other likely cell cycle regulators. Thus in neural progenitor cells, anti-proliferative effects of interferons are not necessarily linked to differentiation.

Original languageEnglish
Pages (from-to)32-38
Number of pages7
JournalJournal of Neuroimmunology
Volume206
Issue number1-2
DOIs
Publication statusPublished - 3 Jan 2009
Externally publishedYes

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