Inhibition of mitochondrial succinate oxidation by antipsychotic medication

Simon Brown, Nicolas L. Taylor

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Fourteen antipsychotics of 5 different chemical classes were tested for their effects on mitochondrial succinate oxidation. Each of the compounds tested, with the exception of haloperidol, phenothiazine and prochlorperazine, inhibited succinate oxidation. The apparent inhibition constant for phenothiazine derivatives declined with increasing values of the partition coefficient.

Original languageEnglish
Pages (from-to)209-211
Number of pages3
JournalVeterinary and human toxicology: an official of journal of the American academy of veterinary and comparative toxicology
Volume42
Issue number4
Publication statusPublished - 1 Aug 2000
Externally publishedYes

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