Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis

Yichuan Pang, Li Su, Yao Fu, Fan Jia, Chenxi Zhang, Xiankun Cao, Wenxin He, Xueqian Kong, Jiake Xu, Jie Zhao, An Qin

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Breast cancer bone metastasis poses significant challenge for therapeutic strategies. Inside the metastatic environment, osteoclasts and tumor cells interact synergistically to promote cancer progression. In this study, the proprotein convertase furin is targeted due to its critical roles in both tumor cell invasion and osteoclast function. Importantly, the furin inhibitor is specifically delivered by bone targeting superparamagnetic iron oxide (SPIO) nanoparticles. Our in vitro and in vivo data demonstrate that this system can effectively inhibit both osteoclastic bone resorption and breast cancer invastion, leading to alleviated osteolysis. Therefore, the bone targeting & furin inhibition nanoparticle system is a promising therapeutic and diagnostic strategy for breast cancer bone metastasis.

Original languageEnglish
Pages (from-to)712-720
Number of pages9
JournalBioactive Materials
Volume6
Issue number3
DOIs
Publication statusPublished - Mar 2021

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