Inhaled diazeniumdiolates (NONOates) as selective pulmonary vasodilators

C-F. Lam, S. Sviri, Kenneth Ilett, Peter Van Heerden

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Selective pulmonary vasoclilators cause vasodilatation limited to the pulmonary vasculature, within well-ventilated lung regions. Selective pulmonary vasodilators ideally cause only a minimal effect on the systemic circulation and improve ventilation/perfusion matching. NONOates are a novel group of chemical compounds that spontaneously and continuously release nitric oxide under physiological conditions, over periods of up to 24 h. Inhaled NONOates retain the benefits of gaseous nitric oxide without many of its therapeutic disadvantages. This review focuses on the therapeutic potential of inhaled NONOates in pulmonary hypertension, other lung conditions associated with right ventricular dysfunction and in asthma. The potential toxicity of NONOates is also discussed.
Original languageEnglish
Pages (from-to)897-909
JournalExpert Opinion on Investigational Drugs
Volume11
Issue number7
Publication statusPublished - 2002

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