Influenza vaccine effectiveness against hospitalisation with influenza in adults in Australia in 2014

A.C. Cheng, T. Kotsimbos, P.M. Kelly, P. Wark, C. Hunter, S. Hewagama, N.D. Friedman, T.M. Korman, G. Simpson, J.W. Upham, S. Bowler, S.j. Senenayake, M. Holmes, L. Irving, Simon Brown, Grant Waterer, D.E. Dwyer, K. Macartney, Christopher Blyth

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15 Citations (Web of Science)

Abstract

© 2015 Elsevier Ltd. We provide estimates of the influenza vaccine protection against hospitalisation with laboratory-confirmed influenza in the 2014 Australian season where the A/H1N1/pdm09 strain predominated. This was performed using a case-test negative study design as part of a national sentinel surveillance system in Australia. Vaccine effectiveness was estimated as (1-OR). ×. 100% where the odds ratio of vaccination in cases vs test negative participants was estimated from a conditional logistic regression. Between April and November, 1692 adult patients were admitted with laboratory-confirmed influenza. Vaccine effectiveness was estimated from 1283 patients with influenza and 1116 test negative patients where vaccination status was ascertained. Vaccination was associated with a reduction in the risk of hospitalisation with influenza of 51.5% (95% CI: 41.6%, 59.7%) in all patients, and a reduction of 50.7% (95% CI: 40.1%, 59.3%) in the target population for vaccination. We estimate that the influenza vaccine was moderately protective against hospitalisation with laboratory-confirmed influenza during the 2014 influenza season in Australia.
Original languageEnglish
Pages (from-to)7352-7356
JournalVaccine
Volume33
Issue number51
DOIs
Publication statusPublished - 2015

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