Influenza antiviral resistance in the Asia-Pacific region during 2011

Sook Kwan Leang, Yi Mo Deng, Robert Shaw, Natalie Caldwell, Pina Iannello, Naomi Komadina, Philippe Buchy, Malinee Chittaganpitch, Dominic E. Dwyer, Peter Fagan, Ann Claire Gourinat, Frances Hammill, Paul F. Horwood, Qiu Sue Huang, Peng Kei Ip, Lance Jennings, Alison Kesson, Tuckweng Kok, Jacob L. Kool, Avram LevyCui Lin, Katie Lindsay, Osmali Osman, Gina Papadakis, Fahimeh Rahnamal, William Rawlinson, Craig Redden, Jennifer Ridgway, I. Ching Sam, Suzanne Svobodova, Amado Tandoc, Geethani Wickramasinghe, Jan Williamson, Noelene Wilson, Mohd Apandi Yusof, Anne Kelso, Ian G. Barr, Aeron C. Hurt

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Despite greater than 99% of influenza A viruses circulating in the Asia-Pacific region being resistant to the adamantane antiviral drugs in 2011, the large majority of influenza A (>97%) and B strains (∼99%) remained susceptible to the neuraminidase inhibitors oseltamivir and zanamivir. However, compared to the first year of the 2009 pandemic, cases of oseltamivir-resistant A(H1N1)pdm09 viruses with the H275Y neuraminidase mutation increased in 2011, primarily due to an outbreak of oseltamivir-resistant viruses that occurred in Newcastle, as reported in Hurt et al. (2011c, 2012a), where the majority of the resistant viruses were from community patients not being treated with oseltamivir. A small number of influenza B viruses with reduced oseltamivir or zanamivir susceptibility were also detected. The increased detection of neuraminidase inhibitor resistant strains circulating in the community and the detection of novel variants with reduced susceptibility are reminders that monitoring of influenza viruses is important to ensure that antiviral treatment guidelines remain appropriate.

Original languageEnglish
Pages (from-to)206-210
Number of pages5
JournalAntiviral Research
Volume97
Issue number2
DOIs
Publication statusPublished - 1 Feb 2013
Externally publishedYes

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