Influence of respiratory tract viral infection on endothelin-1-induced potentiation of cholinergic nerve-mediated contraction in mouse trachea

M.J. Carr, Roy Goldie, Peter Henry

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

1 This study examined the influence of respiratory tract infection with influenza A/PR-8/34 virus on endothelin receptor-mediated modulation of contraction induced by stimulation of cholinergic nerves in mouse isolated trachea.2 The ET(B) receptor-selective agonist, sarafotoxin S6c (30 nM) induced large transient contractions (118 +/- 5% C-max, n = 13; where C-max is the contraction induced by 10 mu M carbachol) of isolated tracheal segments from control mice. The peak contractile response to 30 nM sarafotoxin S6c was significantly lower in preparations from virus-inoculated mice at day 2 (57 +/- 8% C-max, n = 3, P
Original languageEnglish
Pages (from-to)891-898
JournalBritish Journal of Pharmacology
Volume119
DOIs
Publication statusPublished - 1996

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