Influence of respiratory dead space on lung clearance index in preterm infants

R.P. Neumann, Jane Pillow, C. Thamrin, U. Frey, Sven Schulzke

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


© 2015 Elsevier B.V. Lung clearance index (LCI), a marker of ventilation inhomogeneity derived from multiple breath washout (MBW), is used for clinical monitoring and as a key outcome of clinical trials in infants and children with cystic fibrosis. Utility of LCI is controversial in preterm infants with bronchopulmonary dysplasia (BPD) who tend to have high dead space to tidal volume ratio (VD/VT). We investigated the effect of VD/VT on LCI in a cohort of preterm infants with and without BPD and term healthy controls. We analyzed MBW data from 455 infants at a mean (SD) of 43.4 (3.5) w postmenstrual age. VD was estimated from the molar mass signal of an ultrasonic flowmeter (VD,MM). LCI was associated with VD,MM/VT (r2=0.13, p
Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalRespiratory Physiology and Neurobiology
Publication statusPublished - 1 Mar 2016


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